Modulation of immune development and function by intestinal microbiota

被引：256

作者：

Kabat, Agnieszka M. ^{[1
]}

Srinivasan, Naren ^{[1
,2
]}

Maloy, Kevin J. ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

[2] Canc Res UK London Res Inst, Immunobiol Lab, London WC2A 3PX, England

来源：

TRENDS IN IMMUNOLOGY | 2014年 / 35卷 / 11期

基金：

英国惠康基金;

关键词：

microbiota; commensals; mucosal immunity; immune regulation; INNATE LYMPHOID-CELLS; REGULATORY T-CELLS; ARYL-HYDROCARBON RECEPTOR; SEGMENTED FILAMENTOUS BACTERIA; INFLAMMATORY-BOWEL-DISEASE; CD103(+) DENDRITIC CELLS; ROR-GAMMA-T; COMMENSAL BACTERIA; LAMINA PROPRIA; ORAL TOLERANCE;

D O I：

10.1016/j.it.2014.07.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immune system must constantly monitor the gastrointestinal tract for the presence of pathogens while tolerating trillions of commensal microbiota. It is clear that intestinal microbiota actively modulate the immune system to maintain a mutually beneficial relation, but the mechanisms that maintain homeostasis are not fully understood. Recent advances have begun to shed light on the cellular and molecular factors involved, revealing that a range of microbiota derivatives can influence host immune functions by targeting various cell types, including intestinal epithelial cells, mononuclear phagocytes, innate lymphoid cells, and B and T lymphocytes. Here, we review these findings, highlighting open questions and important challenges to overcome in translating this knowledge into new therapies for intestinal and systemic immune disorders.

引用

页码：507 / 517

页数：11

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