Role and potential therapeutic use of antibodies against herpetic infections

被引：9
作者：
Clementi, N. [1 ]
Cappelletti, F. [1 ]
Criscuolo, Elena [1 ]
Castelli, M. [1 ]
Mancini, N. [1 ,2 ]
Burioni, R. [1 ,2 ]
Clementi, M. [1 ,2 ]
机构：
[1] Univ Vita Salute San Raffaele, Microbiol & Virol Unit, Milan, Italy
[2] Osped San Raffaele, Lab Microbiol & Virol, Milan, Italy
来源：
CLINICAL MICROBIOLOGY AND INFECTION | 2017年 / 23卷 / 06期
关键词：
Epitope-based vaccine; Herpesviridae; Humoral immune response; Human monoclonal antibodies; Virus immuno-escape mechanisms; EPSTEIN-BARR-VIRUS; FC-GAMMA RECEPTORS; SIMPLEX-VIRUS; MONOCLONAL-ANTIBODY; CYTOMEGALOVIRUS-INFECTION; INNATE; HERPESVIRUSES; IMMUNITY; VACCINE; NEUTRALIZATION;
D O I：
10.1016/j.cmi.2016.12.023
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Background: The cellular adaptive response directed against herpesviruses is widely described in the scientific literature as a pivotal component of the immune system able to control virus replication. The role of humoral immunity remains unclear and controversial. Aims: Discussing the role of adaptive immunity in herpesvirus infection control, highlighting the potential role of the humoral branch of immunity through the description of human monoclonal antibodies directed against herpesviruses. Sources: PubMed search for relevant publications related to protective immunity against Herpesviridae. Content: This review describes the role of adaptive immunity directed against Herpesviridae, focusing on the human humoral response naturally elicited during their infections. Given the ever-increasing interest in monoclonal antibodies as novel therapeutics, the contribution of humoral immunity in controlling productive infection, during both primary infection and reactivations, is discussed. Implications: Human monoclonal antibodies directed against the different Herpesviridae species may represent novel molecular probes to further characterize the molecular machinery involved in herpesvirus infection; and allow the development of novel therapeutics and effective vaccine strategies. (C) 2017 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：381 / 386
页数：6
相关论文
共 56 条
[1]   Recent advances in the prevention and treatment of congenital cytomegalovirus infections [J].
Adler, Stuart P. ;
Nigro, Giovanni ;
Pereira, Lenore .
SEMINARS IN PERINATOLOGY, 2007, 31 (01) :10-18
[2]   The contrasting IgG-binding interactions of human and herpes simplex virus Fc receptors [J].
Armour, KL ;
Atherton, A ;
Williamson, LM ;
Clark, MR .
BIOCHEMICAL SOCIETY TRANSACTIONS, 2002, 30 :495-500
[3]   Generation and characterization of a monoclonal antibody specific for human herpesvirus 6 variant A immediate-early 2 protein [J].
Arsenault, S ;
Gravel, A ;
Gosselin, J ;
Flamand, L .
JOURNAL OF CLINICAL VIROLOGY, 2003, 28 (03) :284-290
[4]  
Arvin A, 2007, HUMAN HERPESVIRUSES: BIOLOGY, THERAPY, AND IMMUNOPROPHYLAXIS, P700
[5]  
Atanasiu D., 2016, Journal of virology
[6]   Immune response to HHV-6 and implications for immunotherapy [J].
Becerra, Aniuska ;
Gibson, Laura ;
Stern, Lawrence J. ;
Calvo-Calle, J. Mauricio .
CURRENT OPINION IN VIROLOGY, 2014, 9 :154-161
[7]   Ocular Distribution, Spectrum of Activity, and In Vivo Viral Neutralization of a Fully Humanized Anti-Herpes Simplex Virus IgG Fab Fragment following Topical Application [J].
Berdugo, Marianne ;
Larsen, Inna V. ;
Abadie, Claire ;
Deloche, Catherine ;
Kowalczuk, Laura ;
Touchard, Elodie ;
Dubielzig, Richard ;
Brandt, Curtis R. ;
Behar-Cohen, Francine ;
Combette, Jean-Marc .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2012, 56 (03) :1390-1402
[8]   A phase II, double-masked, randomized, placebo-controlled evaluation of a human monoclonal anti-Cytomegalovirus antibody (MSL-109) in combination with standard therapy versus standard therapy alone in the treatment of AIDS patients with Cytomegalovirus retinitis [J].
Borucki, MJ ;
Spritzler, J ;
Asmuth, DM ;
Gnann, J ;
Hirsch, MS ;
Nokta, M ;
Aweeka, F ;
Nadler, PI ;
Sattler, F ;
Alston, B ;
Nevin, TT ;
Owens, S ;
Waterman, K ;
Hubbard, L ;
Caliendo, A ;
Pollard, RB .
ANTIVIRAL RESEARCH, 2004, 64 (02) :103-111
[9]   Herpesviral Fcγ receptors:: culprits attenuating antiviral IgG? [J].
Budt, M ;
Reinhard, H ;
Bigl, A ;
Hengel, H .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2004, 4 (09) :1135-1148
[10]   RECOMBINANT HUMAN FAB TO GLYCOPROTEIN-D NEUTRALIZES INFECTIVITY AND PREVENTS CELL-TO-CELL TRANSMISSION OF HERPES-SIMPLEX VIRUS-1 AND VIRUS-2 IN-VITRO [J].
BURIONI, R ;
WILLIAMSON, RA ;
SANNA, PP ;
BLOOM, FE ;
BURTON, DR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (01) :355-359
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