Modulation of Theta-Band Local Field Potential Oscillations Across Brain Networks With Central Thalamic Deep Brain Stimulation to Enhance Spatial Working Memory

被引：7

作者：

Chang, Ching-Wen ^{[1
]}

Lo, Yu-Chun ^{[2
]}

Lin, Sheng-Huang ^{[3
,4
]}

Yang, Shih-Hung ^{[5
]}

Lin, Hui-Ching ^{[6
]}

Lin, Ting-Chun ^{[1
]}

Li, Ssu-Ju ^{[1
]}

Hsieh, Christine Chin-jung ^{[1
,7
]}

Ro, Vina ^{[1
]}

Chung, Yueh-Jung ^{[6
]}

Chang, Yun-Chi ^{[6
]}

Lee, Chi-Wei ^{[2
,6
]}

Kuo, Chao-Hung ^{[1
,8
,9
]}

Chen, Shin-Yuan ^{[10
,11
]}

Chen, You-Yin ^{[1
,2
,7
]}

机构：

[1] Natl Yang Ming Univ, Dept Biomed Engn, Taipei, Taiwan

[2] Taipei Med Univ, Coll Med Sci & Technol, PhD Program Neural Regenerat Med, Taipei, Taiwan

[3] Hualien Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Neurol, Hualien, Taiwan

[4] Tzu Chi Univ, Sch Med, Dept Neurol, Hualien, Taiwan

[5] Natl Cheng Kung Univ, Dept Mech Engn, Tainan, Taiwan

[6] Natl Yang Ming Univ, Dept & Inst Physiol, Taipei, Taiwan

[7] Natl Yang Ming Univ, Taiwan Int Grad Program Interdisciplinary Neurosc, Acad Sinica, Taipei, Taiwan

[8] Taipei Vet Gen Hosp, Neurol Inst, Dept Neurosurg, Taipei, Taiwan

[9] Univ Washington, Dept Neurol Surg, Seattle, WA 98195 USA

[10] Hualien Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Neurosurg, Hualien, Taiwan

[11] Tzu Chi Univ, Sch Med, Dept Surg, Hualien, Taiwan

来源：

FRONTIERS IN NEUROSCIENCE | 2019年 / 13卷

关键词：

central thalamus; deep brain stimulation; spatial working memory; synaptic plasticity; hippocampal theta oscillation; LONG-TERM POTENTIATION; SYNAPTIC PLASTICITY; HIPPOCAMPAL-THETA; MECHANISMS; ALPHA; DOPAMINE; CONTRASTS; RELEASE; REGION; CORTEX;

D O I：

10.3389/fnins.2019.01269

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Deep brain stimulation (DBS) is a well-established technique for the treatment of movement and psychiatric disorders through the modulation of neural oscillatory activity and synaptic plasticity. The central thalamus (CT) has been indicated as a potential target for stimulation to enhance memory. However, the mechanisms underlying local field potential (LFP) oscillations and memory enhancement by CT-DBS remain unknown. In this study, we used CT-DBS to investigate the mechanisms underlying the changes in oscillatory communication between the CT and hippocampus, both of which are involved in spatial working memory. Local field potentials (LFPs) were recorded from microelectrode array implanted in the CT, dentate gyrus, cornu ammonis (CA) region 1, and CA region 3. Functional connectivity (FC) strength was assessed by LFP-LFP coherence calculations for these brain regions. In addition, a T-maze behavioral task using a rat model was performed to assess the performance of spatial working memory. In DBS group, our results revealed that theta oscillations significantly increased in the CT and hippocampus compared with that in sham controls. As indicated by coherence, the FC between the CT and hippocampus significantly increased in the theta band after CT-DBS. Moreover, Western blotting showed that the protein expressions of the dopamine D1 and alpha 4-nicotinic acetylcholine receptors were enhanced, whereas that of the dopamine D2 receptor decreased in the DBS group. In conclusion, the use of CT-DBS resulted in elevated theta oscillations, increased FC between the CT and hippocampus, and altered synaptic plasticity in the hippocampus, suggesting that CT-DBS is an effective approach for improving spatial working memory.

引用

页数：11

共 71 条

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