How to determine the number of inner-sphere water molecules in lanthanide(III) complexes by 17O NMR spectroscopy.: A technical note

被引：43

作者：

Djanashvili, Kristina ^{[1
]}

Peters, Joop. A. ^{[1
]}

机构：

[1] Delft Univ Technol, Dept Biotechnol, Lab Biocatalysis & Organ Chem, NL-2628 BL Delft, Netherlands

来源：

CONTRAST MEDIA & MOLECULAR IMAGING | 2007年 / 2卷 / 02期

关键词：

lanthanide-induced shifts; bulk magnetic susceptibility; contact shift; hyperfine coupling constant; coordination number; lanthanide-coordinated water; O-17; NMR;

D O I：

10.1002/cmmi.132

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Lanthanide(III) complexes of polyaminocarboxylates are widely used in MRI as contrast agents. The paramagnetic properties of the metal ion contribute to the increase of H-1 relaxation rates, while the chelate offers a stable binding with the metal. The number of water molecules, coordinated directly to the Ln(III) ion, is very important for the relaxivity and, thus, the efficacy of these contrast agents. Here, we describe convenient methods to determine this parameter by measurement of Ln(III)-induced shifts of the water O-17 NMR resonance. Copyright (c) 2007 John Wiley & Sons, Ltd.

引用

页码：67 / 71

页数：5

共 22 条

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