Two new polyhydroxyl polyacetylenes from fruits of Herpetospermum caudigerum

被引：7

作者：

Feng, Xin ^{[1
,2
]}

Zhong, Gejia ^{[2
]}

Dengba, Daji ^{[2
]}

Luo, Jun ^{[3
]}

Du, Shouying ^{[1
]}

机构：

[1] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100029, Peoples R China

[2] China Tibetol Res Ctr, Tibetanmed Inst, Beijing 100101, Peoples R China

[3] China Pharmaceut Univ, Dept Nat Med Chem, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China

来源：

JOURNAL OF NATURAL MEDICINES | 2017年 / 71卷 / 03期

关键词：

Herpetospermum caudigerum; Polyacetylene; NO production; Tibetan medicine; LIGNANS; SEEDS;

D O I：

10.1007/s11418-017-1079-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new polyhydroxy polyacetylenes, herpecaudenes A and B (1 and 2), were isolated from the ethanol extract of fruits of Herpetospermum caudigerum, an important Tibetan medicine. The structures of them were elucidated on the basis of extensive spectroscopic methods including UV, IR, HRESIMS, H-1 and C-13 NMR, HMBC, HSQC, and H-1-H-1 COSY. Compound 2 showed significant inhibitory effects on NO production in LPS-activated RAW 264.7 macrophages with IC50 values of 7.05 +/- 1.59 mu M.

引用

页码：574 / 577

页数：4

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