Are itch and scratching the nausea and vomiting of skin?

被引：5

作者：

Ostadhadi, Sattar ^{[1
,2
,4
]}

Azimi, Ehsan ^{[3
]}

Lerner, Ethan A. ^{[3
]}

Dehpour, Ahmad-Reza ^{[1
,2
,4
]}

机构：

[1] Univ Tehran Med Sci, Expt Med Res Ctr, Tehran, Iran

[2] Univ Tehran Med Sci, Sch Med, Dept Pharmacol, POB 13145-784, Tehran, Iran

[3] Massachusetts Gen Hosp, Cutaneous Biol Res Ctr, Charlestown, MA USA

[4] Univ Tehran Med Sci, Brain & Spinal Cord Injury Res Ctr, Neurosci Inst, Tehran, Iran

来源：

EXPERIMENTAL DERMATOLOGY | 2016年 / 25卷 / 05期

关键词：

itch; nausea; scratching; vomiting; CHEMOTHERAPY-INDUCED NAUSEA; NK1 TACHYKININ RECEPTORS; SUBSTANCE-P; CUTANEOUS MANIFESTATIONS; HISTAMINE-RECEPTORS; AFFERENT NEURONS; NERVE-FIBERS; PRURITUS; RESPONSES; NEUROPEPTIDES;

D O I：

10.1111/exd.12935

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The physiologic similarities between itch and nausea may not be evident initially, but they share the role of repelling irritants and toxins from the body by inducting scratching and vomiting, respectively. In addition, itch and nausea frequently occur together in certain conditions such as uraemia. Here we show that the mechanisms underlying itch and nausea overlap and that advances in either field may influence the identification of novel drug targets, particularly for itch.

引用

页码：340 / 343

页数：4

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