Suprabasin as a novel tumor endothelial cell marker

被引：37

作者：

Alam, Mohammad T. ^{[1
,2
]}

Nagao-Kitamoto, Hiroko ^{[1
]}

Ohga, Noritaka ^{[1
]}

Akiyama, Kosuke ^{[1
]}

Maishi, Nako ^{[1
]}

Kawamoto, Taisuke ^{[1
]}

Shinohara, Nobuo ^{[3
]}

Taketomi, Akinobu ^{[4
]}

Shindoh, Masanobu ^{[2
]}

Hida, Yasuhiro ^{[5
]}

Hida, Kyoko ^{[1
]}

机构：

[1] Hokkaido Univ, Inst Med Genet, Frontier Res Unit, Sapporo, Hokkaido 0600815, Japan

[2] Hokkaido Univ, Grad Sch Dent Med, Dept Oral Pathol & Biol, Sapporo, Hokkaido 0600815, Japan

[3] Hokkaido Univ, Grad Sch Med, Dept Renal & Genitourinary Surg, Sapporo, Hokkaido 0600815, Japan

[4] Hokkaido Univ, Grad Sch Med, Dept Gastroenterol Surg 1, Sapporo, Hokkaido 0600815, Japan

[5] Hokkaido Univ, Grad Sch Med, Dept Cardiovasc & Thorac Surg, Sapporo, Hokkaido 0600815, Japan

来源：

CANCER SCIENCE | 2014年 / 105卷 / 12期

关键词：

Angiogenesis; suprabasin; suprabasin signaling; tumor endothelial cell marker; tumor endothelial cells; PROMOTES ANGIOGENESIS; CANCER; VEGF; ABNORMALITIES; METASTASIS; DISCOVERY; CARCINOMA; RECEPTOR;

D O I：

10.1111/cas.12549

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent studies have reported that stromal cells contribute to tumor progression. We previously demonstrated that tumor endothelial cells (TEC) characteristics were different from those of normal endothelial cells (NEC). Furthermore, we performed gene profile analysis in TEC and NEC, revealing that suprabasin (SBSN) was upregulated in TEC compared with NEC. However, its role in TEC is still unknown. Here we showed that SBSN expression was higher in isolated human and mouse TEC than in NEC. SBSN knockdown inhibited the migration and tube formation ability of TEC. We also showed that the AKT pathway was a downstream factor of SBSN. These findings suggest that SBSN is involved in the angiogenic potential of TEC and may be a novel TEC marker.

引用

页码：1533 / 1540

页数：8

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