A Novel Ca(II) Complex for Inhibiting Growth of Human Nasopharyngeal Carcinoma Cells

被引：0
|
作者：
Dai, Li-Li [1 ]
Wu, Hong-Lin [1 ]
Zhou, Xue-Hua [1 ]
Li, Yuan [1 ]
Luo, Song [1 ]
Chen, Zhao-Hui [1 ]
机构：
[1] Hangzhou Normal Univ, Affiliated Hosp, Dept Otolaryngol Head & Neck Surg, Hangzhou, Zhejiang, Peoples R China
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2017年 / 36卷 / 05期
关键词：
coordination polymer; nasopharyngeal carcinoma; X-ray;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
By using the flexible carboxylic organic ligand H3TATB and 1D chain-like secondary building unit, a new Ca(II)-coordination polymer, namely {[Ca-3(TATB)(2)(H2O)(2)](DMA)(4)}(n) (1, H(3)TATB = 4,4', 4 ''-s-triazine-1,3,5-triyltri-p-aminobenzoate, DMA = N, N-dimethylacetamide) has been synthesized under solvothermal conditions. Single crystal X-ray structural analysis reveals that compound 1 features a non-interpenetrating 3D networks with 1D rhombic channels running along the a axis. The antitumor activity of compound 1 and its corresponding organic ligand H(3)TATB were then investigated against three human nasopharyngeal carcinoma cell lines (CNE1, HONE1 and C666-1) by MTT assay. It was found that compared with H(3)TATB, compound 1 exerted rather potent activities against all of these cell lines.
引用
收藏
页码：1035 / 1038
页数：4
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