Oncologic necessity for the complete removal of residual microcalcifications after neoadjuvant chemotherapy for breast cancer

被引：7

作者：

Lee, Jeeyeon ^{[1
,5
]}

Park, Nora Jee-Young ^{[2
,5
]}

Park, Ho Yong ^{[1
,5
]}

Kim, Wan Wook ^{[1
,5
]}

Kang, Byeongju ^{[1
,5
]}

Keum, Heejung ^{[1
,5
]}

Kim, Hye Jung ^{[3
,5
]}

Kim, Won Hwa ^{[3
,5
]}

Chae, Yee Soo ^{[4
,5
]}

Lee, Soo Jung ^{[4
,5
]}

Lee, In Hee ^{[5
]}

Park, Ji-Young ^{[2
,5
]}

Jung, Jin Hyang ^{[1
,5
]}

机构：

[1] Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea

[2] Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu, South Korea

[3] Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea

[4] Kyungpook Natl Univ, Sch Med, Dept Hematol Oncol, Daegu, South Korea

[5] Kyungpook Natl Univ, Chilgok Hosp, Daegu, South Korea

来源：

SCIENTIFIC REPORTS | 2022年 / 12卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

PREOPERATIVE CHEMOTHERAPY; LESIONS; CALCIFICATIONS; CARCINOMAS; WOMEN;

D O I：

10.1038/s41598-022-24757-7

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The surgical range of breast cancer that shows pathologic complete response (pCR) without change in microcalcifications after neoadjuvant chemotherapy (NAC) is controversial. This study examined whole breast specimens to evaluate the necessity of mastectomy in those cases. The viability of cancer cells around the residual microcalcification was assessed using prospectively collected breast samples to confirm the presence or absence of cancer cells. A total of 144 patients with breast cancer and diffuse microcalcifications were classified into the reduced mass with no change in residual microcalcification (RESMIN, n = 49) and non-RESMIN (n = 95) groups. Five specimens were prospectively evaluated to assess the presence of viable cancer cells around the microcalcification. Tumor responses to NAC were significantly better with high pCR rates in the RESMIN group (p = 0.005 and p = 0.002). The incidence of human epidermal growth factor receptor 2-positive and triple-negative breast cancers was significantly high in the RESMIN group (p = 0.007). Although five (10.2%) patients had locoregional recurrence in the RESMIN group, no local recurrence in the breast was reported. Although pCR was highly estimated, residual cancers, including ductal carcinoma in situ, remained in 80% cases. Therefore, given the weak scientific evidence available currently, complete removal of residual microcalcifications should be considered for oncologic safety.

引用

页数：9

共 33 条

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