Circular dichroism and the interactions of water soluble porphyrins with DNA - A minireview

被引：163
作者：
Pasternack, RF [1 ]
机构：
[1] Swarthmore Coll, Dept Chem, Swarthmore, PA 19081 USA
来源：
CHIRALITY | 2003年 / 15卷 / 04期
关键词：
porphyrins; DNA; circular dichroism; resonance light scattering; supramolecular assemblies; psi-condensates;
D O I：
10.1002/chir.10206
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The size, sign, and profile of induced circular dichroism (CD) features in the Soret region are reliable indicators of the binding modes of porphyrins and metalloporphyrins to DNA. Porphyrins shown (using such CD criteria) to be intercalators in monodispersed DNA duplexes prove extremely useful for the detection and characterization of organized, condensed forms of nucleic acids (psi-condensates). In addition, certain select porphyrin derivatives can form extended assemblies on nonaggregated DNA templates. A combination of CD and resonance light scattering (RLS) measurements allows for sensitive detection and characterization of these porphyrin arrays.
引用
收藏
页码：329 / 332
页数：4
相关论文
共 23 条
[1]  
BLOOMQUIST D, UNPUB
[2]   Resonance light scattering and its application in determining the size, shape, and aggregation number for supramolecular assemblies of chromophores [J].
Collings, PJ ;
Gibbs, EJ ;
Starr, TE ;
Vafek, O ;
Yee, C ;
Pomerance, LA ;
Pasternack, RF .
JOURNAL OF PHYSICAL CHEMISTRY B, 1999, 103 (40) :8474-8481
[3]  
CRONEY J, UNPUB
[4]   AGGREGATION OF CHLOROPHYLL-A PROBED BY RESONANCE LIGHT-SCATTERING SPECTROSCOPY [J].
DEPAULA, JC ;
ROBBLEE, JH ;
PASTERNACK, RF .
BIOPHYSICAL JOURNAL, 1995, 68 (01) :335-341
[5]   BINDING OF MESO-TETRA (4-N-METHYLPYRIDYL) PORPHINE TO DNA [J].
FIEL, RJ ;
MUNSON, BR .
NUCLEIC ACIDS RESEARCH, 1980, 8 (12) :2835-2842
[6]   INTERACTION OF DNA WITH A PORPHYRIN LIGAND - EVIDENCE FOR INTERCALATION [J].
FIEL, RJ ;
HOWARD, JC ;
MARK, EH ;
DATTAGUPTA, N .
NUCLEIC ACIDS RESEARCH, 1979, 6 (09) :3093-3118
[7]   ORIENTATION AND LINEAR DICHROISM CHARACTERISTICS OF PORPHYRIN DNA COMPLEXES [J].
GEACINTOV, NE ;
IBANEZ, V ;
ROUGEE, M ;
BENSASSON, RV .
BIOCHEMISTRY, 1987, 26 (11) :3087-3092
[8]   SELF-ASSEMBLY OF PORPHYRINS ON NUCLEIC-ACID TEMPLATES [J].
GIBBS, EJ ;
TINOCO, I ;
MAESTRE, MF ;
ELLINAS, PA ;
PASTERNACK, RF .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 157 (01) :350-358
[9]   INTERACTIONS OF PORPHYRINS WITH PURIFIED DNA AND MORE HIGHLY ORGANIZED STRUCTURES [J].
GIBBS, EJ ;
MAURER, MC ;
ZHANG, JH ;
REIFF, WM ;
HILL, DT ;
MALICKABLASZKIEWICZ, M ;
MCKINNIE, RE ;
LIU, HQ ;
PASTERNACK, RF .
JOURNAL OF INORGANIC BIOCHEMISTRY, 1988, 32 (01) :39-65
[10]   MODEL COMPUTATIONS ON THE DIFFERENTIAL SCATTERING OF CIRCULARLY POLARIZED-LIGHT (CIDS) BY DENSE MACROMOLECULAR PARTICLES [J].
KELLER, D ;
BUSTAMANTE, C ;
MAESTRE, MF ;
TINOCO, I .
BIOPOLYMERS, 1985, 24 (05) :783-797
123