Monocyte differentiation and antigen-presenting functions

被引：651

作者：

Jakubzick, Claudia V. ^{[1
,2
]}

Randolph, Gwendalyn J. ^{[3
]}

Henson, Peter M. ^{[1
,2
]}

机构：

[1] Natl Jewish Hlth, Dept Pediat, 1400 Jackson St, Denver, CO 80206 USA

[2] Univ Colorado, Dept Immunol & Microbiol, 12800 E 19th Ave, Aurora, CO 80045 USA

[3] Washington Univ, Med Sch, Dept Pathol & Immunol, 660 S Euclid Ave, St Louis, MO 63110 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2017年 / 17卷 / 06期

基金：

美国国家卫生研究院;

关键词：

T FOLLICULAR HELPER; INFLAMMATORY DENDRITIC CELLS; GENE-EXPRESSION PROFILES; IN-VIVO DEPLETION; TISSUE-RESIDENT; CROSS-PRESENTATION; BONE-MARROW; BLOOD MONOCYTES; CUTTING EDGE; LY6C(HI) MONOCYTES;

D O I：

10.1038/nri.2017.28

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Monocytes develop in the bone marrow and represent the primary type of mononuclear phagocyte found in the blood. They were long thought of as a source for tissue macrophages, but recent studies indicate more complex roles for monocytes, both within the circulation and after their migration into tissues and lymphoid organs. In this Review, we discuss the newer concepts underlying the maturation of emigrating monocytes into different classes oftissue macrophages, as well as their potential functions, as monocyte-derived cells, in the tissues. In addition, we consider the emerging roles for monocytes in adaptive immunity as antigen-presenting cells.

引用

页码：349 / 362

页数：14

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