Mother-to-child transmission of human immunodeficiency virus, hepatitis B virus and hepatitis C virus among pregnant women with single, dual or triplex infections of human immunodeficiency virus, hepatitis B virus and hepatitis C virus in Nigeria: A systematic review and meta-analysis

被引：6

作者：

Eleje, George Uchenna ^{[1
,2
]}

Onubogu, Chinyere Ukamaka ^{[3
]}

Fiebai, Preye Owen ^{[4
,5
]}

Mbachu, Ikechukwu Innocent ^{[1
,2
]}

Akaba, Godwin Otuodichinma ^{[6
,7
]}

Loto, Olabisi Morebise ^{[8
,9
]}

Usman, Hadiza Abdullahi ^{[10
,11
]}

Rabiu, Ayyuba ^{[12
,13
]}

Chibuzor, Moriam Taiwo ^{[14
]}

Chukwuanukwu, Rebecca Chinyelu ^{[15
]}

Joe-Ikechebelu, Ngozi Nneka ^{[16
]}

Nwankwo, Chike Henry ^{[17
]}

Kalu, Stephen Okoroafor ^{[18
]}

Ogbuagu, Chukwuanugo Nkemakonam ^{[19
]}

Chukwurah, Shirley Nneka ^{[20
]}

Uzochukwu, Chinwe Elizabeth ^{[21
]}

Oppah, Ijeoma Chioma ^{[5
]}

Ahmed, Aishat ^{[7
]}

Egeonu, Richard Obinwanne ^{[2
]}

Jibuaku, Chiamaka Henrietta ^{[22
]}

Inuyomi, Samuel Oluwagbenga ^{[23
]}

Adesoji, Bukola Abimbola ^{[24
]}

Anyang, Ubong Inyang ^{[7
]}

Ogwaluonye, Uchenna Chukwunonso ^{[22
]}

Emeka, Ekene Agatha ^{[25
]}

Igue, Odion Emmanuel ^{[26
]}

Okoro, Ogbonna Dennis ^{[27
]}

Aja, Prince Ogbonnia ^{[15
]}

Chidozie, Chiamaka Perpetua ^{[15
]}

Ibrahim, Hadiza Sani ^{[13
]}

Aliyu, Fatima Ele ^{[13
]}

Numan, Aisha Ismaila ^{[11
]}

Omoruyi, Solace Amechi ^{[5
]}

Umeononihu, Osita Samuel ^{[1
,2
]}

Okoro, Chukwuemeka Chukwubuikem ^{[2
]}

Nwaeju, Ifeanyi Kingsley ^{[2
]}

Onwuegbuna, Arinze Anthony ^{[28
]}

Umeh, Eric Okechukwu ^{[29
]}

Nweje, Sussan Ifeyinwa ^{[30
]}

Eleje, Lydia Ijeoma ^{[31
]}

Ajuba, Ifeoma Clara ^{[32
]}

Ikwuka, David Chibuike ^{[33
]}

Igbodike, Emeka Philip ^{[34
]}

Chigbo, Chisom God'swill ^{[35
]}

Ebubedike, Uzoamaka Rufina ^{[29
]}

Okafor, Chigozie Geoffrey ^{[2
]}

Obiegbu, Nnaedozie Paul ^{[2
]}

Yakasai, Ibrahim Adamu ^{[12
,13
]}

Ezechi, Oliver Chukwujekwu ^{[36
]}

Ikechebelu, Joseph Ifeanyichukwu ^{[1
,2
]}

机构：

[1] Nnamdi Azikiwe Univ, Dept Obstet & Gynecol, Effect Care Res Unit, PMB 5001, Awka 420007, Anambra State, Nigeria

[2] Nnamdi Azikiwe Univ Teaching Hosp, Dept Obstet & Gynecol, Nnewi, Nnewi, Nigeria

[3] Nnamdi Azikiwe Univ, Dept Paediat, Awka, Nigeria

[4] Univ Port Harcourt, Dept Obstet & Gynecol, Port Harcourt, Nigeria

[5] Univ Port Harcourt, Dept Obstet & Gynecol, Teaching Hosp, Port Harcourt, Nigeria

[6] Univ Abuja, Dept Obstet & Gynecol, Abuja, Nigeria

[7] Univ Abuja, Dept Obstet & Gynecol, Teaching Hosp, Abuja, Nigeria

[8] Obafemi Awolowo Univ, Dept Obstet & Gynecol, Ife, Nigeria

[9] Obafemi Awolowo Univ, Dept Obstet & Gynecol, Teaching Hosp Complex, Ife, Nigeria

[10] Univ Maiduguri, Dept Obstet & Gynecol, Maiduguri, Nigeria

[11] Univ Maiduguri Teaching Hosp, Dept Obstet & Gynecol, Maiduguri, Nigeria

[12] Bayero Univ Kano, Dept Obstet & Gynecol, Kano, Nigeria

[13] Aminu Kano Teaching Hosp, Dept Obstet & Gynecol, Kano, Nigeria

[14] Univ Calabar, Inst Trop Dis Res & Prevent, Teaching Hosp, Cochrane Nigeria, Calabar, Nigeria

[15] Nnamdi Azikiwe Univ, Dept Med Lab Sci, Immunol Unit, Awka, Nigeria

[16] Chukwuemeka Odumegwu Ojukwu Univ, Fac Med, Dept Community Med & Primary Hlth Care, Awka, Nigeria

[17] Nnamdi Azikiwe Univ, Dept Stat, Awka, Nigeria

[18] Nnamdi Azikiwe Univ, HIV Care Dept, HIV Care Lab, Teaching Hosp, Nnewi, Nigeria

[19] Nnamdi Azikiwe Univ, Fac Med, Dept Med Microbiol & Parasitol, Awka, Nigeria

[20] Nnamdi Azikiwe Univ, Fac Med, Dept Med, Gastroenterol Unit, Awka, Nigeria

[21] Nnamdi Azikiwe Univ, Dept Mass Commun, Awka, Nigeria

[22] Nnamdi Azikiwe Univ, Dept Pharmaceut Sci, Awka, Nigeria

[23] Obafemi Awolowo Univ, Dept Phys & Engn Phys, Ife, Nigeria

[24] Obafemi Awolowo Univ, Dept Nursing, Teaching Hosp Complex, Ife, Nigeria

[25] Nnamdi Azikiwe Univ, Fac Med, Dept Family Med, Awka, Nigeria

[26] Obafemi Awolowo Univ, Dept Physiol Sci, Ife, Nigeria

[27] Univ Maiduguri, Fac Vet Med, Dept Parasitol & Entomol, Maiduguri, Nigeria

[28] Nnamdi Azikiwe Univ, Dept Ophthalmol, Awka, Nigeria

[29] Nnamdi Azikiwe Univ, Fac Med, Dept Radiol, Awka, Nigeria

[30] Nnamdi Azikiwe Univ, Dept Nursing, Teaching Hosp, Nnewi, Nigeria

[31] Nnamdi Azikiwe Univ, Dept Educ Fdn, Measurement Evaluat & Res Unit, Awka, Nigeria

[32] Nnamdi Azikiwe Univ, Fac Med, Dept Hematol, Awka, Nigeria

[33] Nnamdi Azikiwe Univ, Dept Human Physiol, Awka, Nigeria

[34] St Georges Hosp Mem Ctr, Dept Obstet & Gynecol, Lagos, Nigeria

[35] Nnamdi Azikiwe Univ, Dept Appl Microbiol, Awka, Nigeria

[36] Nigerian Inst Med Res, Yaba, Nigeria

来源：

SAGE OPEN MEDICINE | 2022年 / 10卷

关键词：

Hepatitis B; hepatitis C virus; human immunodeficiency virus; infectious diseases; mother-to-child transmission; Nigeria; ACTIVE ANTIRETROVIRAL THERAPY; HIV-INFECTION; ELIMINATION; PREVALENCE; HEALTH; RISK;

D O I：

10.1177/20503121221095411

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: To systematically review literature and identify mother-to-child transmission rates of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus among pregnant women with single, dual, or triplex infections of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus in Nigeria. PRISMA guidelines were employed. Searches were on 19 February 2021 in PubMed, Google Scholar and CINAHL on studies published from I February 2001 to 31 January 2021 using keywords: "MTCT," "dual infection," "triplex infection," "HIV," "HBV," and "HCV." Studies that reported mother-to-child transmission rate of at least any of human immunodeficiency virus, hepatitis B virus and hepatitis C virus among pregnant women and their infant pairs with single, dual, or triplex infections of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus in Nigeria irrespective of publication status or language were eligible. Data were extracted independently by two authors with disagreements resolved by a third author. Meta-analysis was performed using the random effects model of DerSimonian and Laird, to produce summary mother-to-child transmission rates in terms of percentage with 95% confidence interval. Protocol was prospectively registered in PROSPERO: CRD42020202070. The search identified 849 reports. After screening titles and abstracts, 25 full-text articles were assessed for eligibility and 18 were included for meta-analysis. We identified one ongoing study. Pooled mother-to-child transmission rates were 2.74% (95% confidence interval: 2.48%-2.99%; 5863 participants; 15 studies) and 55.49% (95% confidence interval: 35.93%-75.04%; 433 participants; three studies), among mother-infant pairs with mono-infection of human immunodeficiency virus and hepatitis B virus, respectively, according to meta-analysis. Overall, the studies showed a moderate risk of bias. The pooled rate of mother-to-child transmission of human immunodeficiency virus was 2.74% and hepatitis B virus was 55.49% among mother-infant pairs with mono-infection of HIV and hepatitis B virus, respectively. No data exists on rates of mother-to-child transmission of hepatitis C virus on mono-infection or mother-to-child transmission of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus among mother-infant pairs with dual or triplex infection of HIV, hepatitis B virus and HCV in Nigeria.

引用

页数：15

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