Cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest

被引:230
作者
Cabral, Joana [1 ,2 ]
Vidaurre, Diego [3 ]
Marques, Paulo [4 ,5 ,6 ]
Magalhaes, Ricardo [4 ,5 ,6 ]
Moreira, Pedro Silva [4 ,5 ,6 ]
Soares, Jose Miguel [4 ,5 ,6 ]
Deco, Gustavo [7 ,8 ,9 ,10 ]
Sousa, Nuno [4 ,5 ,6 ]
Kringelbach, Morten L. [1 ,2 ,11 ]
机构
[1] Univ Oxford, Dept Psychiat, Oxford OX3 7JX, England
[2] Aarhus Univ, Ctr Mus Brain, DK-8000 Aarhus, Denmark
[3] Univ Oxford, Oxford Ctr Human Brain Act, Oxford OX3 7JX, England
[4] Univ Minho, Sch Med, Life & Hlth Sci Res Inst ICVS, P-4710057 Braga, Portugal
[5] ICVS 3Bs PT Govt Associate Lab, P-4710057 Braga, Portugal
[6] Clin Acad Ctr 2CA Braga, P-4710057 Braga, Portugal
[7] Univ Pompeu Fabra, Computat Neurosci Grp, Ctr Brain & Cognit, Barcelona 08018, Spain
[8] ICREA, Barcelona 08010, Spain
[9] Max Planck Inst Human Cognit & Brain Sci, Dept Neuropsychol, D-04103 Leipzig, Germany
[10] Monash Univ, Sch Psychol Sci, Clayton, Vic 3800, Australia
[11] Inst Etud Avancees Paris, F-75004 Paris, France
基金
新加坡国家研究基金会; 英国惠康基金;
关键词
BRAIN ACTIVITY; HUMAN INTELLIGENCE; NETWORKS; CONNECTOME; DYNAMICS; NEUROANATOMY; COMPLEXITY; RESERVE; SINGLE; ROBUST;
D O I
10.1038/s41598-017-05425-7
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Growing evidence has shown that brain activity at rest slowly wanders through a repertoire of different states, where whole-brain functional connectivity (FC) temporarily settles into distinct FC patterns. Nevertheless, the functional role of resting-state activity remains unclear. Here, we investigate how the switching behavior of resting-state FC relates with cognitive performance in healthy older adults. We analyse resting-state fMRI data from 98 healthy adults previously categorized as being among the best or among the worst performers in a cohort study of >1000 subjects aged 50+ who underwent neuropsychological assessment. We use a novel approach focusing on the dominant FC pattern captured by the leading eigenvector of dynamic FC matrices. Recurrent FC patterns - or states - are detected and characterized in terms of lifetime, probability of occurrence and switching profiles. We find that poorer cognitive performance is associated with weaker FC temporal similarity together with altered switching between FC states. These results provide new evidence linking the switching dynamics of FC during rest with cognitive performance in later life, reinforcing the functional role of resting-state activity for effective cognitive processing.
引用
收藏
页数:13
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