Three decades of clinical trials on immunotherapy for human leishmaniases: a systematic review and meta-analysis

被引：3
作者：
Mota, Camila Alves [1 ]
Oyama, Jully [2 ]
Souza Terron Monich, Mariana de [1 ]
Brustolin, Aline avila [1 ]
Perez de Souza, Joao Vitor [2 ]
Murase, Leticia Sayuri [1 ]
Ghiraldi Lopes, Luciana Dias [3 ]
Silva Santos, Thais da [2 ]
Vieira Teixeira, Jorge Juarez [4 ]
Verzignassi Silveira, Thais Gomes [4 ]
机构：
[1] Univ Estadual Maringa, Grad Program Hlth Sci, Maringa, Parana, Brazil
[2] Univ Estadual Maringa, Grad Program Biosci & Physiopathol, Maringa, Parana, Brazil
[3] Univ Estadual Maringa, Lab Clin Virol, Dept Clin Anal & Biomed, Maringa, Parana, Brazil
[4] Univ Estadual Maringa, Lab Leishmaniases, Dept Clin Anal & Biomed, Maringa, Parana, Brazil
来源：
IMMUNOTHERAPY | 2021年 / 13卷 / 08期
关键词：
antiprotozoal agents; humans; immunologic factors; immunotherapy; Leishmania; leishmaniasis; neglected diseases; therapeutics; treatment failure; vaccine; AMERICAN CUTANEOUS LEISHMANIASIS; COLONY-STIMULATING FACTOR; PARENTERAL MEGLUMINE ANTIMONIATE; CANINE VISCERAL LEISHMANIASIS; AZAR DERMAL LEISHMANIASIS; INTERFERON-GAMMA; DOUBLE-BLIND; LEISH-F1+MPL-SE VACCINE; GM-CSF; IMMUNOCHEMOTHERAPY;
D O I：
10.2217/imt-2020-0184
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Aim: Current treatments for leishmaniases are not satisfactory, thus alternatives are needed. We searched for clinical trials with immunotherapeutic approaches for patients with leishmaniasis. Materials & methods: Out of 205 articles, 24 clinical trials were selected, and eight submitted to meta-analysis. Results: A reduction in healing time was observed in patients with tegumentary leishmaniasis treated with pentavalent antimony plus granulocyte-macrophage colony-stimulating factor, and therapeutic vaccines. Overall meta-analysis indicated that immunotherapy associated with the standard chemotherapy generated a significantly reduced risk of treatment failure than the pentavalent antimony alone (p = 0.03). Conclusion: Our review confirmed the efficacy of immunotherapies for the treatment of cutaneous and visceral leishmaniasis and highlighted the importance of clinical trials using immunotherapies for leishmaniases.
引用
收藏
页码：693 / 721
页数：29
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