Adjuvant treatment of colorectal cancer

被引：13
作者：
Beretta, GD [1 ]
Milesi, L [1 ]
Pessi, MA [1 ]
Mosconi, S [1 ]
Labianca, R [1 ]
机构：
[1] Riuniti Hosp, Dept Med Oncol, Gastrointestinal Oncol Unit, I-24128 Bergamo, Italy
来源：
SURGICAL ONCOLOGY-OXFORD | 2004年 / 13卷 / 2-3期
关键词：
colon cancer; rectal cancer; adjuvant therapy; combined therapy; elderly;
D O I：
10.1016/j.suronc.2004.09.008
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colorectal cancer is one of the most frequent causes of cancer deaths. Survival for locoregional colorectal cancer is about 70% overall and 30-60% in stage III patients. Several randomized trials have shown that adjuvant chemotherapy can increase this survival rate. 5-Fluorouracil-based chemotherapy is strongly recommended in this context. There are still some questions about the setting in which patients should be treated as well as the optimal treatment. New data for different schedules and combinations are now available. Physicians have to choose between the different options now available to offer the best treatment to their patients. This Review analyses the current options for adjuvant therapy in colon and rectal cancer. (C) 2004 Elsevier Ltd. All rights reserved.
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收藏
页码：63 / 73
页数：11
相关论文
共 80 条
  • [1] Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer
    Andre, T
    Boni, C
    Mounedji-Boudiaf, L
    Navarro, M
    Tabernero, J
    Hickish, T
    Topham, C
    Zaninelli, M
    Clingan, P
    Bridgewater, J
    Tabah-Fisch, I
    de Gramont, A
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (23) : 2343 - 2351
  • [2] Semimonthly versus monthly regimen of fluorouracil and leucovorin administered for 24 or 36 weeks as adjuvant therapy in stage II and III colon cancer:: Results of a randomized trial
    André, T
    Colin, P
    Louvet, C
    Gamelin, E
    Bouche, O
    Achille, E
    Colbert, N
    Boaziz, C
    Piedbois, P
    Tubiana-Mathieu, N
    Boutan-Laroze, A
    Flesch, M
    Buyse, M
    de Gramont, A
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (15) : 2896 - 2903
  • [3] [Anonymous], 1984, NEW ENGL J MED, V310, P737
  • [4] [Anonymous], 1985, NEW ENGL J MED, V312, P1465
  • [5] 5-fluorouracil plus leucovorin is an effective adjuvant chemotherapy in curatively resected stage III colon cancer: long-term follow-up results of the adjCCA-01 trial
    Arkenau, HT
    Bermann, A
    Rettig, K
    Strohmeyer, G
    Porschen, R
    [J]. ANNALS OF ONCOLOGY, 2003, 14 (03) : 395 - 399
  • [6] *AXIS COLL, 1999, P AN M AM SOC CLIN, V18, pA1031
  • [7] BEDIKIAN AY, 1978, CANCER, V42, P2169, DOI 10.1002/1097-0142(197811)42:5<2169::AID-CNCR2820420513>3.0.CO
  • [8] 2-V
  • [9] BENSON A, 2004, J CLIN ONCOL, V22, P1
  • [10] Beretta GD, 2004, ATLAS OF ENDOANAL AND ENDORECTAL ULTRASONOGRAPHY, P241
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