Myeloid-Derived Suppressor Cells in Bacterial Infections

被引：100
作者：
Ost, Michael [1 ]
Singh, Anurag [1 ]
Peschel, Andreas [2 ]
Mehling, Roman [1 ]
Rieber, Nikolaus [1 ,3 ,4 ]
Hartl, Dominik [1 ]
机构：
[1] Univ Tubingen, Childrens Hosp, Tubingen, Germany
[2] Univ Tubingen, Dept Infect Biol, Interfac Inst Microbiol & Infect Med, Tubingen, Germany
[3] Tech Univ Munich, Dept Pediat, Kinderklin Munchen Schwabing, Klinikum Schwabing,StKM GmbH, D-80290 Munich, Germany
[4] Tech Univ Munich, Klinikum Rechts Isar, D-80290 Munich, Germany
来源：
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2016年 / 6卷
关键词：
MDSC; myeloid-derived suppressor cells; bacteria; infection; immune suppression; sepsis; PSEUDOMONAS-AERUGINOSA INFECTION; NITRIC-OXIDE; IMMUNE-RESPONSE; T-CELLS; TUBERCULOSIS INFECTION; CLINICAL-SIGNIFICANCE; PATTERN-RECOGNITION; CARCINOMA PATIENTS; CYSTIC-FIBROSIS; DENDRITIC CELLS;
D O I：
10.3389/fcimb.2016.00037
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Myeloid-derived suppressor cells (MDSCs) comprise monocytic and granulocytic innate immune cells with the capability of suppressing T- and NK-cell responses. While the role of MDSCs has been studied in depth in malignant diseases, the understanding of their regulation and function in infectious disease conditions has just begun to evolve. Here we summarize and discuss the current view how MDSCs participate in bacterial infections and how this knowledge could be exploited for potential future therapeutics.
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页数：9
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