A rare manifestation of choriocarcinoma syndrome in a child with primary intracranial germ cell tumor and extracranial metastases: A case report and review of the literature

被引：2

作者：

Keenan, Camille ^{[1
]}

Ramirez, Nicole ^{[1
]}

Elijovich, Lucas ^{[2
]}

Klimo, Paul, Jr. ^{[3
]}

Bag, Asim K. ^{[4
]}

Acharya, Sahaja ^{[5
]}

Upadhyaya, Santhosh A. ^{[1
,6
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Oncol, MS 260,262 Danny Thomas Pl, Memphis, TN 38105 USA

[2] Univ Tennessee, Hlth Sci Ctr, Dept Neurol & Neurosurg, Memphis, TN USA

[3] St Jude Childrens Res Hosp, Dept Surg, 332 N Lauderdale St, Memphis, TN 38105 USA

[4] St Jude Childrens Res Hosp, Dept Diagnost Imaging, 332 N Lauderdale St, Memphis, TN 38105 USA

[5] St Jude Childrens Res Hosp, Dept Radiat Oncol, 332 N Lauderdale St, Memphis, TN 38105 USA

[6] Univ Tennessee, Hlth Sci Ctr, Dept Pediat, Memphis, TN USA

来源：

PEDIATRIC BLOOD & CANCER | 2021年 / 68卷 / 06期

基金：

美国国家卫生研究院;

关键词：

arteriovenous fistula; choriocarcinoma syndrome; metastatic intracranial germ cell tumor; serum beta‐ hCG; MANAGEMENT;

D O I：

10.1002/pbc.29000

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Choriocarcinoma syndrome is an uncommon, potentially fatal complication of germ cell tumors (GCTs) in adults, but it is not well documented in children. Pediatric central nervous system (CNS) GCTs comprise a rare group of malignancies not usually associated with extra-CNS metastatic disease. Here, we report the case of a pediatric patient with a suprasellar mixed GCT and pulmonary metastases who presented with intratumoral hemorrhage and stroke. Choriocarcinoma syndrome developed soon after initiating chemotherapy. The primary tumor and pulmonary metastases were successfully treated using a multidisciplinary approach, including neurovascular intervention, chemotherapy, and craniospinal irradiation.

引用

页数：4

共 16 条

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