The concept of extended neighboring order statistics introduced in Asadi et al. (2001) is a general model containing models of ordered random variables that are included in the generalized order statistics. This model also includes several models of ordered random variables that are not included in the generalized order statistics and is a helpful tool in unifying characterization results from several models of ordered random variables. In this paper, some general classes of distributions with many applications in reliability analysis and engineering, such as negative exponential, inverse exponential, Pareto, negative Pareto, inverse Pareto, power function, negative power, beta of the first kind, rectangular, Cauchy, Raleigh, Lomax, etc., have been characterized by using the regression of extended neighboring order statistics and decreasingly ordered random variables.