Cardiac hypertrophy: Targeting Raf/MEK/ERK1/2-signaling

被引：108

作者：

Lorenz, Kristina ^{[1
]}

Schmitt, Joachim P. ^{[1
]}

Vidal, Marie ^{[1
]}

Lohse, Martin J. ^{[1
,2
]}

机构：

[1] Univ Wurzburg, Inst Pharmacol & Toxicol, D-97078 Wurzburg, Germany

[2] Univ Wurzburg, Rudolf Virchow Ctr, DFG Res Ctr Expt Biomed, D-97078 Wurzburg, Germany

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2009年 / 41卷 / 12期

关键词：

Cardiac hypertrophy; ERK1/2; Signaling; ACTIVATED PROTEIN-KINASE; EXTRACELLULAR SIGNAL; DIFFERENTIAL REGULATION; DILATED CARDIOMYOPATHY; INDUCED APOPTOSIS; HEART; INHIBITION; PATHWAY; DYSFUNCTION; MECHANISMS;

D O I：

10.1016/j.biocel.2009.08.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Over the past two decades, basic research has revealed a complex network of regulatory mechanisms that control the ERK1/2-signaling cascade. ERK1/2 mediate cardiac hypertrophy, a major risk factor for the development of arrhythmias, heart failure and sudden death, but also beneficial effects, e.g. protection of the heart from cell death and ischemic injury. Selective targeting of these ambiguous ERK functions could provide a powerful tool in the treatment of cardiac disease. This short review will discuss new mechanistic insights into ERK1/2-dependent development of cardiac hypertrophy and the prospect to translate this knowledge into future therapeutic strategies. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2351 / 2355

页数：5

共 50 条

[41] Specifically targeting ERK1 or ERK2 kills Melanoma cells [J].

Qin, Jianzhong ;

Xin, Hong ;

Nickoloff, Brian J. .

JOURNAL OF TRANSLATIONAL MEDICINE, 2012, 10

[42] HMGB1 enhances mechanical stress-induced cardiomyocyte hypertrophy in vitro via the RAGE/ERK1/2 signaling pathway [J].

Zhang, Lei ;

Yang, Xue ;

Jiang, Guoliang ;

Yu, Ying ;

Wu, Han ;

Su, Yangang ;

Sun, Aijun ;

Zou, Yunzeng ;

Jiang, Hong ;

Ge, Junbo .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2019, 44 (03) :885-892

[43] Regulation of the transcriptional activity of nuclear receptors by the MEK/ERK1/2 pathway [J].

Zassadowski, Fabien ;

Rochette-Egly, Cecile ;

Chomienne, Christine ;

Cassinat, Bruno .

CELLULAR SIGNALLING, 2012, 24 (12) :2369-2377

[44] DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling [J].

Liu, Ruijie ;

van Berlo, Jop H. ;

York, Allen J. ;

Vagnozzi, Ronald J. ;

Maillet, Marjorie ;

Molkentin, Jeffery D. .

CIRCULATION RESEARCH, 2016, 119 (02) :249-+

[45] CircRAPGEF5 acts as a modulator of RAS/RAF/MEK/ERK signaling during colorectal carcinogenesis [J].

Yin, Zhipeng ;

Li, Hao ;

Zhao, Heng ;

Bentum-Ennin, Lutterodt ;

Xia, Yang ;

Wang, Zaibiao ;

Hu, Wanglai ;

Gu, Hao ;

Zhang, Shangxin ;

Li, Guangyun .

HELIYON, 2024, 10 (16)

[46] ICBP90 mediates the ERK1/2 signaling to regulate the proliferation of Jurkat T cells [J].

Fang, Zhiyuan ;

Xing, Feiyue ;

Bronner, Christian ;

Teng, Zhenping ;

Guo, Zhongfeng .

CELLULAR IMMUNOLOGY, 2009, 257 (1-2) :80-87

[47] The Ras/Raf/MEK/ERK signaling pathway and its role in the occurrence and development of HCC [J].

Li, Lei ;

Zhao, Guo-Dong ;

Shi, Zhe ;

Qi, Li-Li ;

Zhou, Li-Yuan ;

Fu, Ze-Xian .

ONCOLOGY LETTERS, 2016, 12 (05) :3045-3050

[48] miR-4510 blocks hepatocellular carcinoma development through RAF1 targeting and RAS/RAF/MEK/ERK signalling inactivation [J].

Ghousein, Amani ;

Mosca, Nicola ;

Cartier, Flora ;

Charpentier, Justine ;

Dupuy, Jean-William ;

Raymond, Anne-Aurelie ;

Bioulac-Sage, Paulette ;

Grosset, Christophe F. .

LIVER INTERNATIONAL, 2020, 40 (01) :240-251

[49] A Rationale for Targeting Extracellular Regulated Kinases ERK1 and ERK2 in Glioblastoma [J].

Hannen, Ricarda ;

Hauswald, Maria ;

Bartsch, Joerg Walter .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2017, 76 (10) :838-847

[50] ERK1/2 can feedback-regulate cellular MEK1/2 levels [J].

Hong, Seung-Keun ;

Wu, Pui-Kei ;

Karkhanis, Mansi ;

Park, Jong-In .

CELLULAR SIGNALLING, 2015, 27 (10) :1939-1948

← 1 2 3 4 5 →