Serum retinol-binding protein: A link between obesity, insulin resistance, and type 2 diabetes

被引：1

作者：

Wolf, George ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Nutr Sci & Toxicol, Berkeley, CA 94720 USA

来源：

NUTRITION REVIEWS | 2007年 / 65卷 / 05期

关键词：

GLUT4; insulin resistance; obesity; RBP4; refinol-binding protein; type; 2; diabetes;

D O I：

10.1301/nr.2007.may.251-256

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Insulin resistance occurs under conditions of obesity, metabolic syndrome, and type 2 diabetes. It was found to be accompanied by down-regulation of the insulin-responsive glucose transporter GLUT4. Decreased adipocyte GLUT4 caused secretion by adipocytes of the serum retinol-binding protein RBP4. Enhanced levels of serum RBP4 appeared to be the signal for the development of systemic insulin resistance both in experimental animals and in humans. In mice, increased levels of serum RBP4 led to impaired glucose uptake into skeletal muscle and increased glucose production by liver, whereas lowered serum RBP4 levels greatly enhanced insulin sensitivity. Thus, a link has been established between obesity and insulin resistance: RBP4, the vitamin A-transport protein secreted into the circulation by adipocytes.

引用

页码：251 / 256

页数：6

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