Chitosan grafted into mesoporous silica nanoparticles as benznidazol carrier for Chagas diseases treatment

被引：41

作者：

Francisco Nhavene, Egidio Paulo ^{[1
]}

da Silva, Wellington Marcos ^{[1
]}

Trivelato Junior, Roberto Reis ^{[3
]}

Gastelois, Pedro Lana ^{[1
]}

Venancio, Tiago ^{[2
]}

Nascimento, Regiane ^{[4
]}

Campos Batista, Ronaldo Junio ^{[4
]}

Machado, Carlos Renato ^{[3
]}

de Almeida Macedo, Waldemar Augusto ^{[1
]}

Barros de Sousa, Edesia Martins ^{[1
]}

机构：

[1] Ctr Desenvolvimento Tecnol Nucl CDTN CNEN, Ave Presidente Antonio Carlos 6627,Campus UFMG, BR-30270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Sao Carlos, Lab Ressonancia Magnet Nucl, Dept Quim, BR-13565905 Sao Paulo, SP, Brazil

[3] Univ Fed Minas Gerais, ICB, Lab Genet Bioquim, Dept Imunol & Bioquim, BR-31270901 Belo Horizonte, MG, Brazil

[4] Univ Fed Ouro Preto, Dept Fis, BR-35400000 Ouro Preto, MG, Brazil

来源：

MICROPOROUS AND MESOPOROUS MATERIALS | 2018年 / 272卷

关键词：

Silica nanoparticles; Surface functionalization; Benznidazol delivery; TRYPANOSOMA-CRUZI; QUANTUM DOTS; GENE TRANSFECTION; DERIVATIVES; MCM-41; IMMOBILIZATION; CYTOTOXICITY; ADSORPTION; MORPHOLOGY; DELIVERY;

D O I：

10.1016/j.micromeso.2018.06.035

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The use of chitosan functionalized silica for benznidazole delivery in the treatment of neglected disease such as Chagas disease is one of the forms not yet explored, but with great potential for this therapy, as little is known about nanoformulations for the treatment of Chagas disease. In this work, we used chitosan-succinate covalently attached to the surface pore of MSNs to act as anchor for benznidazole as a delivery system. The samples were characterized structurally and chemically with multiple techniques. The applicability of functionalized MSNs as platforms for benznidazole delivery into T. cruzi parasites was assessed. The results demonstrate that the proposed system is a potential promising nanoplatform for drug and gene delivery targeting neglected diseases such as Chagas disease.

引用

页码：265 / 275

页数：11

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