Prognostic values of aldehyde dehydrogenase 1 isoenzymes in ovarian cancer

被引：14
作者：
Ma, Yu-mei [1 ]
Zhao, Shan [2 ]
机构：
[1] Hebei Med Univ, Hosp 2, Dept Pathol, 215 Heping West Rd, Shijiazhuang 050000, Peoples R China
[2] Hebei Med Univ, Hosp 2, Dept Canc Div 2, Shijiazhuang 050000, Peoples R China
来源：
ONCOTARGETS AND THERAPY | 2016年 / 9卷
关键词：
ALDH1; cancer stem cell; prognosis; KM plotter; hazard ratio; STEM-LIKE CELLS; BREAST-CANCER; POOR-PROGNOSIS; SURFACE EPITHELIUM; MICROARRAY DATA; ANALYSIS TOOL; EXPRESSION; RESISTANCE; SURVIVAL; MARKER;
D O I：
10.2147/OTT.S101063
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aldehyde dehydrogenase 1 (ALDH1) activity has been used as a functional stem cell marker to isolate cancer stem cells in different cancer types, including ovarian cancer. However, which ALDH1's isoenzymes are contributing to ALDH1 activity in ovarian cancer remains elusive. In addition, the prognostic value of an individual ALDH1 isoenzyme in ovarian cancer is not clear. Thus, we accessed the prognostic value of ALDH1 isoenzymes in ovarian cancer patients through the "Kaplan-Meier plotter" online database, which can be used to determine the effect of the genes on ovarian cancer prognosis. We found that high mRNA expression of five ALDH1 isoenzymes, such as ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, and ALDH1L1, was not correlated with overall survival (OS) for all 1,306 ovarian cancer patients. In addition, all five of the ALDH1 isoenzymes' high mRNA expression was found to be uncorrelated with OS in serous cancer or endometrioid cancer patients. However, ALDH1A3's high mRNA expression is associated with worse OS in grade II ovarian cancer patients, hazard ratio (HR) 1.53 (1.14-2.07), P=0.005. ALDH1A2's high mRNA expression is significantly associated with worse OS in TP53 wild-type ovarian cancer patients, HR 2.86 (1.56-5.08), P=0.00036. In addition, ALDH1A3's high mRNA expression is significantly associated with better OS in TP53 wild-type ovarian cancer patients, HR 0.56 (0.32-1.00), P=0.04. Our results indicate that although ALDH1 isoenzyme mRNA might not be a prognostic marker for overall ovarian cancer patients, some isoenzymes, such as ALDH1A2 and ALDH1A3, might be a good prognostic marker for some types of ovarian cancer patients.
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页码：1981 / 1988
页数：8
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