Radiologically isolated aquaporin-4 antibody neuromyelitis optica spectrum disorder

被引：7

作者：

Abdel-Mannan, Omar ^{[1
]}

Klein, Ainat ^{[2
]}

Zipori, Anat Bachar ^{[2
]}

Ben-Sira, Liat ^{[3
]}

Fattal-valevski, Aviva ^{[4
]}

Hacohen, Yael ^{[1
]}

Meirson, Hadas ^{[4
]}

机构：

[1] UCL, Fac Brain Sci, UCL Queen Sq Inst Neurol, Queen Sq MS Ctr, 10-12 Russell Sq, London WC1B 5EH, England

[2] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Ophthalmol, Sackler Fac Med, Tel Aviv, Israel

[3] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Pediat Radiol, Sackler Fac Med, Tel Aviv, Israel

[4] Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Pediat Neurol, Tel Aviv, Israel

来源：

MULTIPLE SCLEROSIS JOURNAL | 2022年 / 28卷 / 04期

关键词：

Neuromyelitis optica spectrum disorder; aquaporin-4; antibody; paediatric demyelination; radiologically isolated syndrome; DIAGNOSTIC-CRITERIA;

D O I：

10.1177/13524585221074947

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Aquaporin-4 antibody (AQP4-Ab) Neuromyelitis Optica Spectrum Disorder (NMOSD) is a rare neuroinflammatory syndrome presenting predominantly with optic neuritis and transverse myelitis. We report a case of radiologically isolated longitudinally extensive optic neuritis in an asymptomatic 12-year-old female with positive serum AQP4-Ab, with resolution of imaging changes after immune therapy. By contrast to patients with radiologically isolated syndrome, of which some will never convert to multiple sclerosis, the pathogenicity of AQP4-Ab in the context of sub-clinical disease, supported treatment in our patient. Given the severe morbidity in AQP4-Ab NMOSD, prognostic biomarkers for disease severity are required to guide optimal therapy for patients.

引用

页码：676 / 679

页数：4

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