Dried blood spots in doping analysis

被引：27
作者：
Yuan, Yuling [1 ,2 ]
Xu, Youxuan [2 ]
Lu, Jianghai [2 ]
机构：
[1] Beijing Sport Univ, Sch Sport Sci, 48 Xinxi Rd, Beijing, Peoples R China
[2] China Antidoping Agcy, Food & Drug Doping Control Lab, 1 Anding Rd, Beijing, Peoples R China
来源：
BIOANALYSIS | 2021年 / 13卷 / 07期
关键词：
anabolic steroids; anti-doping; DBS collection; derivatization; dried blood spots; hematocrit; mass spectrometry; TANDEM MASS-SPECTROMETRY; GROWTH-HORMONE ABUSE; LIQUID-CHROMATOGRAPHY; TESTOSTERONE ESTERS; INTERNAL STANDARD; ANABOLIC-STEROIDS; WHOLE-BLOOD; CHEMICAL DERIVATIZATION; SUBCUTANEOUS INJECTION; BIOLOGICAL SAMPLES;
D O I：
10.4155/bio-2021-0019
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of dried blood spot (DBS) detection methods for doping agents have been developed in the last two decades. The DBS technique minimizes invasiveness and reduces storage and shipping costs. Recently, the World Anti-Doping Agency announced the use of DBS for the 2022 Beijing Winter Olympic Games and Paralympic Games owing to the advantages of the DBS application in routine doping control. Therefore the further development of detection methods for doping agents in DBS is important and urgent. This review summarizes five aspects of DBS application in doping analysis: sample collection, storage conditions, pretreatment, instrumentation and validation according to the Prohibited List issued by the World Anti-Doping Agency, and proposes some suggestions for future studies of DBS in doping analysis.
引用
收藏
页码：587 / 604
页数：18
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