Identification and characterization of degradation products of Remdesivir using liquid chromatography/mass spectrometry†

被引：13

作者：

Dadinaboyina, S. Babu ^{[1
,2
,3
]}

Yerra, Naga Veera ^{[1
,3
]}

Adimoolam, Bala Manikantha ^{[1
,3
]}

Parsa, Sivaramakrishna ^{[4
]}

Bathini, Nagendra Babu ^{[2
,3
]}

Thota, Jagadeshwar Reddy ^{[1
,3
]}

机构：

[1] Indian Inst Chem Technol, CSIR, Dept Analyt & Struct Chem, Hyderabad 500007, Andhra Pradesh, India

[2] Indian Inst Chem Technol, CSIR, Dept Fluoroagrochem, Hyderabad 500007, Andhra Pradesh, India

[3] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India

[4] ZunaChem Pvt Ltd, Dept Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

NEW JOURNAL OF CHEMISTRY | 2021年 / 45卷 / 16期

关键词：

CORONAVIRUS;

D O I：

10.1039/d1nj00160d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Remdesivir (RDV), a nucleoside analogue prodrug, is used to treat viral diseases including COVID-19. The drug (RDV) was stressed under acidic, basic and neutral hydrolysis, oxidation, photolysis, and thermal conditions according to the International Council for Harmonisation (ICH) prescribed guidelines Q1A (R2). A total of nine degradation products were formed under acidic (DP1-DP5), basic (DP5-DP8) and neutral (DP5) hydrolysis, and oxidation (DP9) stress conditions, whereas the drug was found to be stable under thermal and photolytic stress conditions. The structures of the degradation products were elucidated by using a simple and rapid ultra high-performance liquid chromatography coupled to electrospray interface with quadrupole time-of-flight tandem mass spectrometer (UPLC/ESI-Q-TOF-MS/MS) method.

引用

页码：7217 / 7224

页数：8

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