Status epilepticus increases CSF levels of neuron-specific enolase and alters the blood-brain barrier

被引：114

作者：

Correale, J

Rabinowicz, AL

Heck, CN

Smith, TD

Loskota, WJ

DeGiorgio, CM

机构：

[1] FLENI, Inst Invest Neurol Dr Raul Carrea, RA-1428 Buenos Aires, DF, Argentina

[2] USC, Sch Med, LAC USC Med Ctr, Dept Neurol,Neurol Serv,EEG Lab, Los Angeles, CA USA

[3] USC, Sch Med, LAC USC Med Ctr, Dept Mol Microbiol & Immunol,Neurol Serv,EEG Lab, Los Angeles, CA USA

[4] USC, Sch Med, LAC USC Med Ctr, Dept Anesthesiol,Neurol Serv,EEG Lab, Los Angeles, CA USA

[5] USC, Sch Med, LAC USC Med Ctr, Dept Neurol Surg,Neurol Serv,EEG Lab, Los Angeles, CA USA

[6] USC, Sch Med, LAC USC Med Ctr, Clin Res Ctr, Los Angeles, CA USA

来源：

NEUROLOGY | 1998年 / 50卷 / 05期

关键词：

D O I：

10.1212/WNL.50.5.1388

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neuron-specific enolase (NSE) is a sensitive marker of brain damage in stroke, global ischemia, and coma. Serum NSE is also correlated with the duration and outcome of status epilepticus (SE). CSF-NSE levels have not been previously reported in SE. We report the CSF concentrations of NSE in 11 patients with cryptogenic/remote symptomatic SE. CSF obtained within 24 hours of SE showed increased concentrations of NSE in 9 of 11 patients. The mean CSF-NSE for the group was elevated compared with the levels for normal control subjects (30.8 +/- 18.33 versus 10.76 +/- 3.08 ng/mL; p = 0.002). Further, CSF-NSE levels were elevated compared with simultaneous serum levels in the same group of patients (p = 0.01). In addition, the CSF/serum albumin ratio (QAlb), a measure of the integrity of the blood-brain barrier, was increased in SE patients compared with control individuals (33.4 versus 4.79 X 10(-3);p = 0.0001). An increase of QAlb correlated with CSF-NSE (r(s) = 0.66, p = 0.04) and serum NSE levels (r(s) = 0.83, p = 0.004). CSF-NSE is a promising in vivo marker for brain injury after SE.

引用

页码：1388 / 1391

页数：4