MicroRNAs: Emerging biomarkers for atrial fibrillation

被引：62
作者：
Komal, Sumra [1 ]
Yin, Jian-Jian [1 ]
Wang, Shu-Hui [1 ]
Huang, Chen-Zheng [1 ]
Tao, Hai-Long [2 ]
Dong, Jian-Zeng [2 ]
Han, Sheng-Na [1 ]
Zhang, Li-Rong [1 ]
机构：
[1] Zhengzhou Univ, Sch Basic Med Sci, Dept Pharmacol, Zhengzhou 450001, Henan, Peoples R China
[2] Zhengzhou Univ, Affiliated Hosp 1, Cardiol Dept, Zhengzhou, Henan, Peoples R China
来源：
JOURNAL OF CARDIOLOGY | 2019年 / 74卷 / 5-6期
基金：
中国国家自然科学基金;
关键词：
Atrial fibrillation; MicroRNA; Single nucleotide polymorphism; Biomarkers; SINGLE-NUCLEOTIDE POLYMORPHISM; CIRCULATING MICRORNAS; MYOCARDIAL FIBROSIS; EXPRESSION PROFILES; ALTERED EXPRESSION; CATHETER ABLATION; UP-REGULATION; RISK; CONDUCTION; MIR-133;
D O I：
10.1016/j.jjcc.2019.05.018
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Atrial fibrillation (AF) causes severe cardiac dysrhythmia among patients with cardiovascular diseases. AF increases the risk of stroke and heart failure and is a growing public health concern. AF is also associated with various disease conditions such as hypertension, coronary artery disease, aging, and diabetes mellitus. The mechanism underlying AF is not completely understood due to its complexity. However, experimental and clinical data have revealed that the prevalence of this disease is associated with atrial arrhythmogenic remodeling. Currently, there are no biomarkers that are available for the early diagnosis of AF. Several studies have proposed microRNAs (miRNAs) as useful biomarkers for the diagnosis of AF due to their stability and easy availability both in atrial tissue and circulating blood. miRNAs play an important role in the development of the heart. The dysregulation of miRNA expression is associated with cardiac remodeling. Genetic factors strongly contribute to the pathogenesis of AF. Recently, single nucleotide polymorphisms (SNPs) in various genes and miRNAs have been reported to be associated with AF. The aim of this review was to discuss the correlation between SNPs in miRNAs and AF, including those miRNAs that are commonly reported as potential biomarkers for AF. (C) 2019 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：475 / 482
页数：8
相关论文
共 98 条
  • [31] Signal Transducer and Activator of Transcription 3/MicroRNA-21 Feedback Loop Contributes to Atrial Fibrillation by Promoting Atrial Fibrosis in a Rat Sterile Pericarditis Model
    Huang, Zhengrong
    Chen, Xiao-jun
    Qian, Cheng
    Dong, Qian
    Ding, Dan
    Wu, Qiong-feng
    Li, Jing
    Wang, Hong-fei
    Li, Wei-hua
    Xie, Qiang
    Cheng, Xiang
    Zhao, Ning
    Du, Yi-mei
    Liao, Yu-hua
    [J]. CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 2016, 9 (07)
  • [32] miR126 positively regulates mast cell proliferation and cytokine production through suppressing Spred1
    Ishizaki, Takuma
    Tamiya, Taiga
    Taniguchi, Koji
    Morita, Rimpei
    Kato, Reiko
    Okamoto, Fuyuki
    Saeki, Kazuko
    Nomura, Masatoshi
    Nojima, Yoshihisa
    Yoshimura, Akihiko
    [J]. GENES TO CELLS, 2011, 16 (07) : 803 - 814
  • [33] Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens
    Jia, Xiaoming
    Han, Buhm
    Onengut-Gumuscu, Suna
    Chen, Wei-Min
    Concannon, Patrick J.
    Rich, Stephen S.
    Raychaudhuri, Soumya
    de Bakker, Paul I. W.
    [J]. PLOS ONE, 2013, 8 (06):
  • [34] Jin Y, 2018, HEART LUNG CIRC
  • [35] Jin Y, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0032155, 10.1371/journal.pone.0030419]
  • [36] MicroRNA regulation of cardiac conduction and arrhythmias
    Kim, Gene H.
    [J]. TRANSLATIONAL RESEARCH, 2013, 161 (05) : 381 - 392
  • [37] Atrial fibrillation in women: treatment
    Ko, Darae
    Rahman, Faisal
    Martins, Maria A. P.
    Hylek, Elaine M.
    Ellinor, Patrick T.
    Schnabel, Renate B.
    Benjamin, Emelia J.
    Christophersen, Ingrid E.
    [J]. NATURE REVIEWS CARDIOLOGY, 2017, 14 (02) : 113 - 124
  • [38] miRBase: annotating high confidence microRNAs using deep sequencing data
    Kozomara, Ana
    Griffiths-Jones, Sam
    [J]. NUCLEIC ACIDS RESEARCH, 2014, 42 (D1) : D68 - D73
  • [39] The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury
    Kriegel, Alison J.
    Liu, Yong
    Fang, Yi
    Ding, Xiaoqiang
    Liang, Mingyu
    [J]. PHYSIOLOGICAL GENOMICS, 2012, 44 (04) : 237 - 244
  • [40] microRNA single polynucleotide polymorphism influences on microRNA biogenesis and mRNA target specificity
    Kroliczewski, Jaroslaw
    Sobolewska, Aleksandra
    Lejnowski, Dawid
    Collawn, James F.
    Bartoszewski, Rafal
    [J]. GENE, 2018, 640 : 66 - 72
12345678910