MicroRNAs: Emerging biomarkers for atrial fibrillation

被引：63
作者：
Komal, Sumra [1 ]
Yin, Jian-Jian [1 ]
Wang, Shu-Hui [1 ]
Huang, Chen-Zheng [1 ]
Tao, Hai-Long [2 ]
Dong, Jian-Zeng [2 ]
Han, Sheng-Na [1 ]
Zhang, Li-Rong [1 ]
机构：
[1] Zhengzhou Univ, Sch Basic Med Sci, Dept Pharmacol, Zhengzhou 450001, Henan, Peoples R China
[2] Zhengzhou Univ, Affiliated Hosp 1, Cardiol Dept, Zhengzhou, Henan, Peoples R China
来源：
JOURNAL OF CARDIOLOGY | 2019年 / 74卷 / 5-6期
基金：
中国国家自然科学基金;
关键词：
Atrial fibrillation; MicroRNA; Single nucleotide polymorphism; Biomarkers; SINGLE-NUCLEOTIDE POLYMORPHISM; CIRCULATING MICRORNAS; MYOCARDIAL FIBROSIS; EXPRESSION PROFILES; ALTERED EXPRESSION; CATHETER ABLATION; UP-REGULATION; RISK; CONDUCTION; MIR-133;
D O I：
10.1016/j.jjcc.2019.05.018
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Atrial fibrillation (AF) causes severe cardiac dysrhythmia among patients with cardiovascular diseases. AF increases the risk of stroke and heart failure and is a growing public health concern. AF is also associated with various disease conditions such as hypertension, coronary artery disease, aging, and diabetes mellitus. The mechanism underlying AF is not completely understood due to its complexity. However, experimental and clinical data have revealed that the prevalence of this disease is associated with atrial arrhythmogenic remodeling. Currently, there are no biomarkers that are available for the early diagnosis of AF. Several studies have proposed microRNAs (miRNAs) as useful biomarkers for the diagnosis of AF due to their stability and easy availability both in atrial tissue and circulating blood. miRNAs play an important role in the development of the heart. The dysregulation of miRNA expression is associated with cardiac remodeling. Genetic factors strongly contribute to the pathogenesis of AF. Recently, single nucleotide polymorphisms (SNPs) in various genes and miRNAs have been reported to be associated with AF. The aim of this review was to discuss the correlation between SNPs in miRNAs and AF, including those miRNAs that are commonly reported as potential biomarkers for AF. (C) 2019 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：475 / 482
页数：8
相关论文
共 98 条
[1]   Role of miR-21 in the pathogenesis of atrial fibrosis [J].
Adam, Oliver ;
Loehfelm, Bjoern ;
Thum, Thomas ;
Gupta, Shashi K. ;
Puhl, Sarah-Lena ;
Schaefers, Hans-Joachim ;
Boehm, Michael ;
Laufs, Ulrich .
BASIC RESEARCH IN CARDIOLOGY, 2012, 107 (05)
[2]  
Ardekani Ali M., 2010, Avicenna Journal of Medical Biotechnology, V2, P161
[3]   Chronic Atrial Fibrillation Increases MicroRNA-21 in Human Atrial Myocytes Decreasing L-Type Calcium Current [J].
Barana, Adriana ;
Matamoros, Marcos ;
Dolz-Gaiton, Pablo ;
Perez-Hernandez, Marta ;
Amoros, Irene ;
Nunez, Mercedes ;
Sacristan, Sandra ;
Pedraz, Alvaro ;
Pinto, Angel ;
Fernandez-Aviles, Francisco ;
Tamargo, Juan ;
Delpon, Eva ;
Caballero, Ricardo .
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 2014, 7 (05) :861-U192
[4]   MicroRNAs: Target Recognition and Regulatory Functions [J].
Bartel, David P. .
CELL, 2009, 136 (02) :215-233
[5]   The microRNA.org resource: targets and expression [J].
Betel, Doron ;
Wilson, Manda ;
Gabow, Aaron ;
Marks, Debora S. ;
Sander, Chris .
NUCLEIC ACIDS RESEARCH, 2008, 36 :D149-D153
[6]   Constitutively Active Acetylcholine-Dependent Potassium Current Increases Atrial Defibrillation Threshold by Favoring Post-Shock Re-Initiation [J].
Bingen, Brian O. ;
Askar, Said F. A. ;
Neshati, Zeinab ;
Feola, Iolanda ;
Panfilov, Alexander V. ;
de Vries, Antoine A. F. ;
Pijnappels, Daniel A. .
SCIENTIFIC REPORTS, 2015, 5
[7]   MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice [J].
Callis, Thomas E. ;
Pandya, Kumar ;
Seok, Hee Young ;
Tang, Ru-Hang ;
Tatsuguchi, Mariko ;
Huang, Zhan-Peng ;
Chen, Jian-Fu ;
Deng, Zhongliang ;
Gunn, Bronwyn ;
Shumate, Janelle ;
Willis, Monte S. ;
Selzman, Craig H. ;
Wang, Da-Zhi .
JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (09) :2772-2786
[8]   miR-208b upregulation interferes with calcium handling in HL-1 atrial myocytes: Implications in human chronic atrial fibrillation [J].
Canon, Susana ;
Caballero, Ricardo ;
Herraiz-Martinez, Adela ;
Perez-Hernandez, Marta ;
Lopez, Begona ;
Atienza, Felipe ;
Jalife, Jose ;
Hove-Madsen, Leif ;
Delpon, Eva ;
Bernad, Antonio .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2016, 99 :162-173
[9]   The role of connexin40 in atrial fibrillation [J].
Chaldoupi, Sevasti-Maria ;
Loh, Peter ;
Hauer, Richard N. W. ;
de Bakker, Jacques M. T. ;
van Rijen, Harold V. M. .
CARDIOVASCULAR RESEARCH, 2009, 84 (01) :15-23
[10]   The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation [J].
Chen, JF ;
Mandel, EM ;
Thomson, JM ;
Wu, QL ;
Callis, TE ;
Hammond, SM ;
Conlon, FL ;
Wang, DZ .
NATURE GENETICS, 2006, 38 (02) :228-233
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