Chronotherapy for Hypertension

被引:94
作者
Bowles, N. P. [1 ]
Thosar, S. S. [1 ]
Herzig, M. X. [1 ]
Shea, S. A. [1 ]
机构
[1] Oregon Hlth & Sci Univ, Oregon Inst Occupat Hlth Sci, 3181 SW Sam Jackson Pk Rd L606, Portland, OR 97239 USA
关键词
Hypertension; Chronotherapy; Blood pressure; Non-dipping; Sleep; Circadian rhythms; AMBULATORY BLOOD-PRESSURE; OBSTRUCTIVE SLEEP-APNEA; CHRONIC KIDNEY-DISEASE; POSITIVE AIRWAY PRESSURE; CONVERTING ENZYME-INHIBITOR; GLOMERULAR-FILTRATION-RATE; TREATMENT-TIME REGIMEN; STAGE RENAL-DISEASE; LOW-DOSE ASPIRIN; CARDIOVASCULAR EVENTS;
D O I
10.1007/s11906-018-0897-4
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Purpose of ReviewGiven the emerging knowledge that circadian rhythmicity exists in every cell and all organ systems, there is increasing interest in the possible benefits of chronotherapy for many diseases. There is a well-documented 24-h pattern of blood pressure with a morning surge that may contribute to the observed morning increase in adverse cardiovascular events. Historically, antihypertensive therapy involves morning doses, usually aimed at reducing daytime blood pressure surges, but an absence of nocturnal dipping blood pressure is also associated with increased cardiovascular risk.Recent FindingsTo more effectively reduce nocturnal blood pressure and still counteract the morning surge in blood pressure, a number of studies have examined moving one or more antihypertensives from morning to bedtime dosing. More recently, such studies of chronotherapy have studied comorbid populations including obstructive sleep apnea, chronic kidney disease, or diabetes.SummaryHere, we summarize major findings from recent research in this area (2013-2017). In general, nighttime administration of antihypertensives improved overall 24-h blood pressure profiles regardless of disease comorbidity. However, inconsistencies between studies suggest a need for more prospective randomized controlled trials with sufficient statistical power. In addition, experimental studies to ascertain mechanisms by which chronotherapy is beneficial could aid drug design and guidelines for timed administration.
引用
收藏
页数:24
相关论文
共 235 条
[1]   Chronic kidney disease, anemia, and incident stroke in a middle-aged, community-based population: The ARIC Study [J].
Abramson, JL ;
Jurkovitz, CT ;
Vaccarino, V ;
Weintraub, WS ;
McClellan, W .
KIDNEY INTERNATIONAL, 2003, 64 (02) :610-615
[2]   Comparison of Left Atrial Mechanical Function in Nondipper versus Dipper Hypertensive Patients: A Speckle Tracking Study [J].
Acar, Goksel ;
Bulut, Mustafa ;
Arslan, Kursat ;
Alizade, Elnur ;
Ozkan, Birol ;
Alici, Gokhan ;
Tanboga, Ibrahim Halil ;
Yazicioglu, Mehmet Vefik ;
Akcakoyun, Mustafa ;
Esen, Ali Metin .
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES, 2013, 30 (02) :164-170
[3]   Prognostic importance of ambulatory blood pressure recordings in patients with chronic kidney disease [J].
Agarwal, R ;
Andersen, MJ .
KIDNEY INTERNATIONAL, 2006, 69 (07) :1175-1180
[4]   Does nocturnal blood pressure fall in people of African and South Asian descent differ from that in European white populations? A systematic review and meta-analysis [J].
Agyemang, C ;
Bhopal, R ;
Bruijnzeels, M ;
Redekop, WK .
JOURNAL OF HYPERTENSION, 2005, 23 (05) :913-920
[5]   Efficacy of the Combination of Amlodipine and Valsartan in Patients With Hypertension Uncontrolled With Previous Monotherapy: The Exforge in Failure After Single Therapy (EX-FAST) Study [J].
Allemann, Yves ;
Fraile, Belen ;
Lambert, Michel ;
Barbier, Michaela ;
Ferber, Philippe ;
Izzo, Joseph L., Jr. .
JOURNAL OF CLINICAL HYPERTENSION, 2008, 10 (03) :185-194
[6]   Standards of Medical Care in Diabetes-2014 [J].
不详 .
DIABETES CARE, 2014, 37 :S14-S80
[7]  
[Anonymous], 2015, WORLD J CARDIOVASC D
[8]   Circadian Pattern of Ambulatory Blood Pressure in Hypertensive Patients With and Without Type 2 Diabetes [J].
Ayala, Diana E. ;
Moya, Ana ;
Crespo, Juan J. ;
Castineira, Carmen ;
Dominguez-Sardina, Manuel ;
Gomara, Sonia ;
Sineiro, Elvira ;
Mojon, Artemio ;
Fontao, Maria J. ;
Hermida, Ramon C. .
CHRONOBIOLOGY INTERNATIONAL, 2013, 30 (1-2) :99-115
[9]   Cardiovascular Risk of Resistant Hypertension: Dependence on Treatment-Time Regimen of Blood Pressure-Lowering Medications [J].
Ayala, Diana E. ;
Hermida, Ramon C. ;
Mojon, Artemio ;
Fernandez, Jose R. .
CHRONOBIOLOGY INTERNATIONAL, 2013, 30 (1-2) :340-352
[10]   SEX DIFFERENCES IN THE ADMINISTRATION-TIME-DEPENDENT EFFECTS OF LOW-DOSE ASPIRIN ON AMBULATORY BLOOD PRESSURE IN HYPERTENSIVE SUBJECTS [J].
Ayala, Diana E. ;
Hermida, Ramon C. .
CHRONOBIOLOGY INTERNATIONAL, 2010, 27 (02) :345-362