Nickel-Catalyzed Denitrogenative Cyclization of 1,2,3,4-Benzothiatriazin-1,1(2H)-dioxides with Arynes To Synthesize Biary lSultams

被引：8

作者：

Thorat, Vijaykumar H. ^{[1
]}

Tsai, Yu-Lin ^{[1
]}

Huang, Yong-Ran ^{[1
]}

Cheng, Chien-Hong ^{[2
]}

Hsieh, Jen-Chieh ^{[1
]}

机构：

[1] Tamkang Univ, Dept Chem, New Taipei 251301, Taiwan

[2] Natl Tsing Hua Univ, Dept Chem, Hsinchu 300044, Taiwan

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 15期

关键词：

SULFONAMIDES; ANNULATION; SULTAMS; DERIVATIVES; INHIBITORS;

D O I：

10.1021/acs.orglett.2c00920

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report the nickel-catalyzed denitrogenative cyclization reaction of 1,2,3,4-benzothiatriazine-1,1-dioxideswith arynes to generate the polysubstituted biaryl sultams withtolerance of a wide diversity of substituents on every subunit. Themechanistic study indicates that the reaction is initiated by theformation of a diradical species, which reacts with a nickel complexto form a nickelacycle intermediate and carries out the subsequentcyclization through insertion of an aryne.

引用

页码：2915 / 2920

页数：6

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