Low infectivity of Plasmodium falciparum gametocytes to Anopheles gambiae following treatment with sulfadoxine-pyrimethamine in Mali

被引:31
作者
Beavogui, Abdoul H. [1 ,3 ]
Djimde, Abdoulaye A. [1 ]
Gregson, Aric [2 ]
Toure, Abdoulaye M. [1 ]
Dao, Adama [1 ]
Coulibaly, Boubacar [1 ]
Ouologuem, Dinkorma [1 ]
Fofana, Bakary [1 ]
Sacko, Adama [1 ]
Tekete, Mamadou [1 ]
Kone, Aminatou [1 ]
Niare, Oumou [1 ]
Wele, Mamadou [1 ]
Plowe, Christopher V. [2 ]
Picot, Stephane [3 ]
Doumbo, Ogobara K. [1 ]
机构
[1] Univ Bamako, Malaria Res & Training Ctr, Dept Epidemiol Parasit Dis, Bamako, Mali
[2] Univ Maryland, Sch Med, Howard Hughes Med Inst, Ctr Vaccine Dev, Baltimore, MD 21201 USA
[3] Univ Lyon 1, Malaria Res Unit, EA 4170, Fac Med, F-69373 Lyon, France
关键词
Plasmodium falciparum; Gametocytes; Sulfadoxine-pyrimethamine; Infectivity; Anopheles gambiae; Mali; INTERMITTENT PREVENTIVE TREATMENT; DIHYDROFOLATE-REDUCTASE; DIHYDROPTEROATE SYNTHASE; MOSQUITO TRANSMISSION; PROTECTIVE IMMUNITY; MOLECULAR-BASIS; MALARIA; CHLOROQUINE; RESISTANCE; MUTATIONS;
D O I
10.1016/j.ijpara.2010.04.010
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Sulfadoxine-pyrimethamine (SP) treatment increases the rate of gametocyte carriage and selects SP resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS), raising concerns of increased malaria transmission and spread of drug resistance. In a setting in Mali where SP was highly efficacious, we measured the prevalence of DHFR and DHPS mutations in P. falciparum infections with microscopy-detected gametocytes following SP treatment, and used direct feeding to assess infectivity to Anopheles gambiae sensu lato. Children and young adults presenting with uncomplicated malaria were treated with SP or chloroquine and followed for 28 days. Gametocyte carriage peaked at 67% 1 week after treatment with a single dose of SP. Those post-SP gametocytes carried significantly more DHFR and DHPS mutations than pre-treatment asexual parasites from the same population. Only 0.5% of 1728 mosquitoes fed on SP-treated gametocyte carriers developed oocysts, while 11% of 198 mosquitoes fed on chloroquine-treated gametocyte carriers were positive for oocysts. This study shows that in an area of high SP efficacy, although SP treatment sharply increased gametocyte carriage, the infectiousness of these gametocytes to the vector may be very low. Accurate and robust methods for measuring infectivity are needed to guide malaria control interventions that affect transmission. (C) 2010 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:1213 / 1220
页数:8
相关论文
共 59 条
[1]   PLASMODIUM-FALCIPARUM - PARASITES DEFECTIVE IN EARLY STAGES OF GAMETOCYTOGENESIS [J].
ALANO, P ;
ROCA, L ;
SMITH, D ;
READ, D ;
CARTER, R ;
DAY, K .
EXPERIMENTAL PARASITOLOGY, 1995, 81 (02) :227-235
[2]   Increased gametocytemia after treatment: An early parasitological indicator of emerging sulfadoxine-pyrimethamine resistance in falciparum malaria [J].
Barnes, Karen I. ;
Little, Francesca ;
Mabuza, Aaron ;
Mngomezulu, Nicros ;
Govere, John ;
Durrheim, David ;
Roper, Cally ;
Watkins, Bill ;
White, Nicholas J. .
JOURNAL OF INFECTIOUS DISEASES, 2008, 197 (11) :1605-1613
[3]   Experimental infection of the neotropical malaria vector Anopheles darlingi by human patient-derived Plasmodium vivax in the Peruvian Amazon [J].
Bharti, Ajay R. ;
Chuquiyauri, Raul ;
Brouwer, Kimberly C. ;
Stancil, Jeffrey ;
Lin, Jessica ;
Llanos-Cuentas, Alejandro ;
Vinetz, Joseph M. .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2006, 75 (04) :610-616
[4]   Comparison of artificial membrane feeding with direct skin feeding to estimate infectiousness of Plasmodium falciparum gametocyte carriers to mosquitoes [J].
Bonnet, S ;
Gouagna, C ;
Safeukui, I ;
Meunier, JY ;
Boudin, C .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2000, 94 (01) :103-106
[5]   The effect of partial host immunity on the transmission of malaria parasites [J].
Buckling, A ;
Read, AF .
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2001, 268 (1483) :2325-2330
[6]   Antimalarial drugs and the mosquito transmission of Plasmodium [J].
Butcher, GA .
INTERNATIONAL JOURNAL FOR PARASITOLOGY, 1997, 27 (09) :975-987
[7]  
Carter R, 1979, Bull World Health Organ, V57 Suppl 1, P37
[8]   Transmission-blocking activities of quinine, primaquine, and artesunate [J].
Chotivanich, Kesinee ;
Sattabongkot, Jetsumon ;
Udomsangpetch, Rachanee ;
Looareesuwan, Sornchai ;
Day, Nicholas P. J. ;
Coleman, Russell E. ;
White, Nicholas J. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (06) :1927-1930
[9]   PLASMODIUM-FALCIPARUM - EFFECT OF CHLOROQUINE, HALOFANTRINE AND PYRIMETHAMINE ON THE INFECTIVITY OF GAMETOCYTES FOR ANOPHELES-STEPHENSI MOSQUITOS [J].
CHUTMONGKONKUL, M ;
MAIER, WA ;
SEITZ, HM .
ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1992, 86 (02) :103-110
[10]   Effect of intermittent preventive treatment of malaria on health and education in schoolchildren: a cluster-randomised, double-blind, placebo-controlled trial [J].
Clarke, Sian E. ;
Jukes, Matthew C. H. ;
Njagi, J. Kiambo ;
Khasakhala, Lincoln ;
Cundill, Bonnie ;
Otido, Julius ;
Crudder, Christopher ;
Estambale, Benson B. A. ;
Brooker, Simon .
LANCET, 2008, 372 (9633) :127-138