Long non-coding RNAs in non-small cell lung cancer as biomarkers and therapeutic targets

被引：127

作者：

Chen, Jing ^{[1
]}

Wang, Rui ^{[1
]}

Zhang, Kai ^{[1
]}

Chen, Long-Bang ^{[1
]}

机构：

[1] Nanjing Univ, Sch Med, Jinling Hosp, Dept Med Oncol, Nanjing 210002, Jiangsu, Peoples R China

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2014年 / 18卷 / 12期

基金：

中国国家自然科学基金;

关键词：

long non-coding RNA; non-small cell lung cancer; biomarker; molecular target; EPITHELIAL-MESENCHYMAL TRANSITION; POOR-PROGNOSIS; BREAST-CANCER; UP-REGULATION; MEG3; GENE; EXPRESSION; CARCINOMA; MALAT-1; GROWTH;

D O I：

10.1111/jcmm.12431

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lung cancer-associated mortality is the most common cause of cancer death worldwide. Non-coding RNAs (ncRNAs), with no protein-coding ability, have multiple biological roles. Long non-coding RNAs (lncRNAs) are a recently characterized class of ncRNAs that are over 200 nucleotides in length. Many lncRNAs have the ability of facilitating or inhibiting the development and progression of tumours, including non-small cell lung cancer (NSCLC). Because of their fundamental roles in regulating gene expression, along with their involvement in the biological mechanisms underlying tumourigenesis, they are a promising class of tissue- and/or blood-based cancer biomarkers. In this review, we highlight the emerging roles of lncRNAs in NSCLC, and discuss their potential clinical applications as diagnostic and prognostic markers and as therapeutic targets.

引用

页码：2425 / 2436

页数：12

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