On the potential of natural products in the discovery of pharma leads: A case for reassessment

被引：76

作者：

Danishefsky, Samuel ^{[1
,2
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

[2] Columbia Univ, New York, NY 10027 USA

来源：

NATURAL PRODUCT REPORTS | 2010年 / 27卷 / 08期

关键词：

D O I：

10.1039/c003211p

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The central proposition advanced herein is that complex target oriented synthesis, enabled by historic advances in methodology, has enormously expanded the scope of the possible. Accordingly, natural products, a proven long-term source of pharma discovery, re-emerge as potentially valuable elements for synthesis-driven pharma exploitation.

引用

页码：1114 / 1116

页数：3

共 5 条

[1] Therapeutic effect against human xenograft tumors in nude mice by the third generation microtubule stabilizing epothilones [J].

Chou, Ting-Chao ;

Zhang, Xiuguo ;

Zhong, Zi-Yang ;

Li, Yong ;

Feng, Li ;

Eng, Sara ;

Myles, David R. ;

Johnson, Robert, Jr. ;

Wu, Nian ;

Yin, Ye Ingrid ;

Wilson, Rebecca M. ;

Danishefsky, Samuel J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (35) :13157-13162

[2] The total synthesis of (+)-migrastatin [J].

Gaul, C ;

Njardarson, JT ;

Danishefsky, SJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (20) :6042-6043

[3] Diverted Total Synthesis Leads to the Generation of Promising Cell-Migration Inhibitors for Treatment of Tumor Metastasis: In vivo and Mechanistic Studies on the Migrastatin Core Ether Analog [J].

Oskarsson, Thordur ;

Nagorny, Pavel ;

Krauss, Isaac J. ;

Perez, Lucy ;

Mandal, Mihirbaran ;

Yang, Guangli ;

Ouerfelli, Ouathek ;

Xiao, Danhua ;

Moore, Malcolm A. S. ;

Massague, Joan ;

Danishefsky, Samuel J. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (09) :3224-3228

[4] Discovery of (E)-9,10-dehydroepothilones through chemical synthesis:: On the emergence of 26-trifluoro-(E)-9,10-dehydro-12,13-desoxyepothilone B as a promising anticancer drug candidate [J].

Rivkin, A ;

Yoshimura, F ;

Gabarda, AE ;

Cho, YS ;

Chou, TC ;

Dong, HJ ;

Danishefsky, SJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (35) :10913-10922

[5] Small molecule natural products in the discovery of therapeutic agents: The synthesis connection [J].

Wilson, Rebecca M. ;

Danishefsky, Samuel J. .

JOURNAL OF ORGANIC CHEMISTRY, 2006, 71 (22) :8329-8351

← 1 →