Synthesis and characterization of multifunctional hyperbranched polyesters as prospective contrast agents for targeted MRI

被引：25

作者：

Sideratou, Zili ^{[1
]}

Tsiourvas, Dimitris ^{[1
]}

Theodossiou, Theodossis ^{[1
]}

Fardis, Michael ^{[2
]}

Paleos, Constantinos M. ^{[1
]}

机构：

[1] NCSR Demokritos, Inst Phys Chem, Athens 15310, Greece

[2] NCSR Demokritos, Inst Mat Sci, Athens 15310, Greece

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 14期

关键词：

MRI contrast agents; Gd(III) complexes; Biodegradable polymers; Hyperbranched polymers; Folate; DRUG-DELIVERY; GENE DELIVERY; GADOLINIUM(III) COMPLEXES; DENDRITIC POLYMERS; FOLATE RECEPTOR; PAMAM DENDRIMER; ACID; SYSTEMS; DESIGN;

D O I：

10.1016/j.bmcl.2010.05.055

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Based on a commercially available hyperbranched aliphatic polyester, novel multifunctional gadolinium complexes were prepared bearing protective PEG chains, a folate targeting ligand and EDTA or DTPA chelate moieties. Their relatively high water relaxivity values coupled with biodegradability of the hyperbranched scaffold, folate receptor specificity render these non-toxic dendritic polymers promising candidates for MRI applications. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4177 / 4181

页数：5

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