Abyssomicin Monomers and Dimers from the Marine-Derived Streptomyces koyangensis SCSIO 5802

被引：38

作者：

Huang, Hongbo ^{[1
]}

Song, Yongxiang ^{[1
]}

Li, Xin ^{[2
]}

Wang, Xin ^{[2
]}

Ling, Chunyao ^{[1
]}

Qjn, Xiangjing ^{[1
]}

Zhou, Zhenbin ^{[1
]}

Li, Qinglian ^{[1
]}

Wei, Xiaoyi ^{[3
]}

Ju, Jianhua ^{[1
]}

机构：

[1] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China

[2] Ocean Univ China, Sch Med & Pharm, Qingdao Natl Lab Marine Sci & Technol, Qingdao 260000, Peoples R China

[3] Chinese Acad Sci, South China Bot Garden, Key Lab Plant Conservat & Sustainable Utilizat, Guangzhou 510650, Guangdong, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2018年 / 81卷 / 08期

基金：

中国国家自然科学基金;

关键词：

SPIROTETRONATE METABOLITES; VERRUCOSISPORA STRAIN;

D O I：

10.1021/acs.jnatprod.8b00448

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new abyssomicin monomers designated neoabyssomicins D (1), E (2), and A2 (3) and the two dimeric neoabyssomicins F (4) and G (5) were discovered from the marine-derived Streptomyces koyangensis SCSIO 5802, and their structures rigorously elucidated. Neoabyssomicin D (1) possesses an unprecedented 8/5/5/7 ring skeleton, the biosynthesis of which (as well as 2) is proposed herein. Additionally, dimeric agents 4 and 5 were found to be active against methicillin-resistant Staphylococcus aureus and vesicular stomatitis virus, respectively.

引用

页码：1892 / 1898

页数：7

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