Monocyte to high-density lipoprotein cholesterol ratio in patients with diabetes mellitus and diabetic nephropathy

被引：56
|
作者：
Karatas, Ahmet [1 ]
Turkmen, Ercan [2 ]
Erdem, Emre [3 ]
Dugeroglu, Harun [4 ]
Kaya, Yasemin [4 ]
机构：
[1] Ordu Univ, Fac Med, Dept Nephrol, Ordu, Turkey
[2] Ordu State Hosp, Nephrol Clin, Ordu, Turkey
[3] Samsun Dialysis Clin, Samsun Dialysis, Samsun, Turkey
[4] Ordu Univ, Fac Med, Dept Internal Med, Ordu, Turkey
来源：
BIOMARKERS IN MEDICINE | 2018年 / 12卷 / 09期
关键词：
diabetes mellitus; diabetic nephropathy; inflammation; monocyte count; monocyte to high-density lipoprotein cholesterol ratio; urine albumin to creatinine ratio; HDL CHOLESTEROL; CARDIOVASCULAR-DISEASE; PREDICTS; EPIDEMIOLOGY; RECRUITMENT; ASSOCIATION; MECHANISMS; MORTALITY; EVENTS;
D O I：
10.2217/bmm-2018-0048
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: We investigated the relationship of monocyte to high-density lipoprotein cholesterol ratio (MHR) with diabetes mellitus and diabetic nephropathy. Methods & Results: A total of 220 diabetes mellitus patients and 70 healthy controls were enrolled. There was no difference in an MHR between normoalbuminuric diabetic patients and the healthy controls. The MHR in patients with diabetic nephropathy was significantly higher than that of both the normoalbuminuric diabetic patients and the healthy controls. There was a significant positive correlation between urine albumin to creatinine ratio and the MHR. In multivariate linear regression analysis, the MHR was independently correlated with urine albumin to creatinine ratio. Conclusion: An increased MHR may be a biomarker for diabetic nephropathy.
引用
收藏
页码：953 / 959
页数：7
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