Exosomes: Versatile Nano Mediators of Immune Regulation

被引：89

作者：

Li, Qi ^{[1
]}

Wang, Helei ^{[2
]}

Peng, Hourong ^{[1
]}

Ting Huyan ^{[1
]}

Cacalano, Nicholas A. ^{[3
]}

机构：

[1] Northwestern Polytech Univ, Sch Life Sci, Key Lab Space Biosci & Space Biotechnol, 127 YouyiXilu, Xian 710072, Shaanxi, Peoples R China

[2] First Hosp Jilin Univ, Dept Gastrointestinal Surg, Changchun 130021, Jilin, Peoples R China

[3] UCLA, Dept Radiat Oncol, David Geffen Sch Med, Los Angeles, CA 90095 USA

来源：

CANCERS | 2019年 / 11卷 / 10期

基金：

中国国家自然科学基金;

关键词：

exosome; immunocyte; immunoregulation; immunotherapy; natural killer cells; CELL-DERIVED-EXOSOMES; MATURE DENDRITIC CELLS; CD8(+) CTL RESPONSES; T-LYMPHOCYTE RESPONSES; NATURAL-KILLER-CELLS; EXTRACELLULAR VESICLES; FAS LIGAND; CANCER-IMMUNOTHERAPY; ANTITUMOR IMMUNITY; B-LYMPHOCYTES;

D O I：

10.3390/cancers11101557

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

One of many types of extracellular vesicles (EVs), exosomes are nanovesicle structures that are released by almost all living cells that can perform a wide range of critical biological functions. Exosomes play important roles in both normal and pathological conditions by regulating cell-cell communication in cancer, angiogenesis, cellular differentiation, osteogenesis, and inflammation. Exosomes are stable in vivo and they can regulate biological processes by transferring lipids, proteins, nucleic acids, and even entire signaling pathways through the circulation to cells at distal sites. Recent advances in the identification, production, and purification of exosomes have created opportunities to exploit these structures as novel drug delivery systems, modulators of cell signaling, mediators of antigen presentation, as well as biological targeting agents and diagnostic tools in cancer therapy. This review will examine the functions of immunocyte-derived exosomes and their roles in the immune response under physiological and pathological conditions. The use of immunocyte exosomes in immunotherapy and vaccine development is discussed.

引用

页数：21

共 142 条

[11]

Bianco Nicole R, 2007, Methods Mol Biol, V380, P443

[12] TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/ζ complex [J].