The use of hepatitis a vaccination in Italy: an economic evaluation

被引:12
作者
Demicheli, V [1 ]
Carniglia, E [1 ]
Fucci, S [1 ]
机构
[1] ASL 20, Serv Epidemiol, Alessandria & Cochrane Vaccines Field, I-15100 Alessandria, Italy
关键词
hepatitis A vaccine; economics; cost-effectiveness analysis;
D O I
10.1016/S0264-410X(03)00136-1
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We report on the conduct and results of an economic model of two different strategies of vaccination against hepatitis A in Italy. In strategy 1 (universal vaccination), all newborns are vaccinated simultaneously with MMR at 15 months and all 12 year olds are vaccinated with combined hepatitis A and B vaccine. In strategy 2 (contacts' vaccination) only subjects with a close social and spatial relationship with the sick are vaccinated. In strategy 1 costs per avoided case and net costs per avoided case values are always very high. Net costs become very low when newborns and 12 year olds are vaccinated, and become negative (indicating a potential gain) when 12 year olds are vaccinated. From an economic viewpoint, universal vaccination appears recommendable only in epidemic conditions. For strategy 2 our model shows that cost for avoidable case are very low and net costs for avoided case are always negative, showing the potential presence of an absolute benefit. We conclude that in Italy mass vaccination appears economically worthwhile only during epidemics but vaccination of contacts is an economically worthwhile routine measure. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2250 / 2257
页数:8
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