A solute binding protein of Streptococcus pneumoniae iron transport

被引：39

作者：

Tai, SS ^{[1
]}

Yu, CL ^{[1
]}

Lee, JK ^{[1
]}

机构：

[1] Howard Univ, Dept Microbiol, Washington, DC 20059 USA

来源：

FEMS MICROBIOLOGY LETTERS | 2003年 / 220卷 / 02期

关键词：

iron transport; hemin; hemoglobin; Streptococcus pneumoniae;

D O I：

10.1016/S0378-1097(03)00135-6

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Streptococcus pneumoniae causes considerable morbidity and mortality throughout the world. Iron acquisition is an important virulence factor for bacterial pathogens. Two loci, piu, and pia, were identified as responsible for the hemoglobin utilization of S. pneumoniae. The binding activity and surface accessibility of the solute binding protein of PiuA were studied. PiuA is a lipoprotein, binds hemin and hemoglobin, resides on the cytoplasmic membrane, and is not exposed on the surface of S. pneumoniae. The localization of PiuA has implications in its role in hemoglobin utilization and possible use as a pneumococcal vaccine. (C) 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Microbiological Societies.

引用

页码：303 / 308

页数：6

共 20 条

[1]

BORDIER C, 1981, J BIOL CHEM, V256, P1604

[2]

Braun V, 1998, MET IONS BIOL SYST, V35, P67

[3] Characterization of pit, a Streptococcus pneumoniae iron uptake ABC transporter [J].