Reprogramming Enhancers to Drive Metastasis

被引：9

作者：

Mostoslavsky, Raul ^{[1
,2
,3
]}

Bardeesy, Nabeel ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Canc Ctr, Boston, MA 02114 USA

[2] Harvard Med Sch, Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02114 USA

[3] Broad Inst Harvard & MIT, Cambridge, MA 02142 USA

来源：

CELL | 2017年 / 170卷 / 05期

关键词：

PANCREATIC-CANCER; PROGRESSION;

D O I：

10.1016/j.cell.2017.08.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acquired molecular changes can promote the spreading of primary tumor cells to distant tissues. In this issue of Cell, Roe et al. show that metastatic progression of pancreatic cancer involves large-scale enhancer reprogramming by Foxa1, which activates transcriptional program specifying early endodermal stem cells.

引用

页码：823 / 825

页数：3

共 10 条

[1] Metastatic progression is associated with dynamic changes in the local microenvironment [J].

Aiello, Nicole M. ;

Bajor, David L. ;

Norgard, Robert J. ;

Sahmoud, Amine ;

Bhagwat, Neha ;

Pham, Minh N. ;

Cornish, Toby C. ;

Iacobuzio-Donahue, Christine A. ;

Vonderheide, Robert H. ;

Stanger, Ben Z. .

NATURE COMMUNICATIONS, 2016, 7

[2] Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver [J].

Costa-Silva, Bruno ;

Aiello, Nicole M. ;

Ocean, Allyson J. ;

Singh, Swarnima ;

Zhang, Haiying ;

Thakur, Basant Kumar ;

Becker, Annette ;

Hoshino, Ayuko ;

Mark, Milica Tesic ;

Molina, Henrik ;

Xiang, Jenny ;

Zhang, Tuo ;

Theilen, Till-Martin ;

Garcia-Santos, Guillermo ;

Williams, Caitlin ;

Ararso, Yonathan ;

Huang, Yujie ;

Rodrigues, Goncalo ;

Shen, Tang-Long ;

Labori, Knut Jorgen ;

Lothe, Inger Marie Bowitz ;

Kure, Elm H. ;

Hernandez, Jonathan ;

Doussot, Alexandre ;

Ebbesen, Saya H. ;

Grandgenett, Paul M. ;

Hollingsworth, Michael A. ;

Jain, Maneesh ;

Mallya, Kavita ;

Batra, Surinder K. ;

Jarnagin, William R. ;

Schwartz, Robert E. ;

Matei, Irina ;

Peinado, Hector ;

Stanger, Ben Z. ;

Bromberg, Jacqueline ;

Lyden, David .

NATURE CELL BIOLOGY, 2015, 17 (06) :816-+

[3] Tracking the Evolution of Non-Small-Cell Lung Cancer [J].

Jamal-Hanjani, M. ;

Wilson, G. A. ;

McGranahan, N. ;

Birkbak, N. J. ;

Watkins, T. B. K. ;

Veeriah, S. ;

Shafi, S. ;

Johnson, D. H. ;

Mitter, R. ;

Rosenthal, R. ;

Salm, M. ;

Horswell, S. ;

Escudero, M. ;

Matthews, N. ;

Rowan, A. ;

Chambers, T. ;

Moore, D. A. ;

Turajlic, S. ;

Xu, H. ;

Lee, S. -M. ;

Forster, M. D. ;

Ahmad, T. ;

Hiley, C. T. ;

Abbosh, C. ;

Falzon, M. ;

Borg, E. ;

Marafioti, T. ;

Lawrence, D. ;

Hayward, M. ;

Kolvekar, S. ;

Panagiotopoulos, N. ;

Janes, S. M. ;

Thakrar, R. ;

Ahmed, A. ;

Blackhall, F. ;

Summers, Y. ;

Shah, R. ;

Joseph, L. ;

Quinn, A. M. ;

Crosbie, P. A. ;

Naidu, B. ;

Middleton, G. ;

Langman, G. ;

Trotter, S. ;

Nicolson, M. ;

Remmen, H. ;

Kerr, K. ;

Chetty, M. ;

Gomersall, L. ;

Fennell, D. A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (22) :2109-2121

[4] SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b [J].

Kugel, Sita ;

Sebastian, Carlos ;

Fitamant, Julien ;

Ross, Kenneth N. ;

Saha, Supriya K. ;

Jain, Esha ;

Gladden, Adrianne ;

Arora, Kshitij S. ;

Kato, Yasutaka ;

Rivera, Miguel N. ;

Ramaswamy, Sridhar ;

Sadreyev, Ruslan I. ;

Goren, Alon ;

Deshpande, Vikram ;

Bardeesy, Nabeel ;

Mostoslavsky, Raul .

CELL, 2016, 165 (06) :1401-1415

[5] Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer [J].

Makohon-Moore, Alvin P. ;

Zhang, Ming ;

Reiter, Johannes G. ;

Bozic, Ivana ;

Allen, Benjamin ;

Kundu, Deepanjan ;

Chatterjee, Krishnendu ;

Wong, Fay ;

Jiao, Yuchen ;

Kohutek, Zachary A. ;

Hong, Jungeui ;

Attiyeh, Marc ;

Javier, Breanna ;

Wood, Laura D. ;

Hruban, Ralph H. ;

Nowak, Martin A. ;

Papadopoulos, Nickolas ;

Kinzler, Kenneth W. ;

Vogelstein, Bert ;

Iacobuzio-Donahue, Christine A. .

NATURE GENETICS, 2017, 49 (03) :358-366

[6] Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis [J].

McDonald, Oliver G. ;

Li, Xin ;

Saunders, Tyler ;

Tryggvadottir, Rakel ;

Mentch, Samantha J. ;

Warmoes, Marc O. ;

Word, Anna E. ;

Carrer, Alessandro ;

Salz, Tal H. ;

Natsume, Sonoko ;

Stauffer, Kimberly M. ;

Makohon-Moore, Alvin ;

Zhong, Yi ;

Wu, Hao ;

Wellen, Kathryn E. ;

Locasale, Jason W. ;

Iacobuzio-Donahue, Christine A. ;

Feinberg, Andrew P. .

NATURE GENETICS, 2017, 49 (03) :367-376

[7] EMT and Dissemination Precede Pancreatic Tumor Formation [J].

Rhim, Andrew D. ;

Mirek, Emily T. ;

Aiello, Nicole M. ;

Maitra, Anirban ;

Bailey, Jennifer M. ;

McAllister, Florencia ;

Reichert, Maximilian ;

Beatty, Gregory L. ;

Rustgi, Anil K. ;

Vonderheide, Robert H. ;

Leach, Steven D. ;

Stanger, Ben Z. .

CELL, 2012, 148 (1-2) :349-361

[8] Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling [J].

Weissmueller, Susann ;

Manchado, Eusebio ;

Saborowski, Michael ;

Morris, John P. ;

Wagenblast, Elvin ;

Davis, Carrie A. ;

Moon, Sung-Hwan ;

Pfister, Neil T. ;

Tschaharganeh, Darjus F. ;

Kitzing, Thomas ;

Aust, Daniela ;

Markert, Elke K. ;

Wu, Jianmin ;

Grimmond, Sean M. ;

Pilarsky, Christian ;

Prives, Carol ;

Biankin, Andrew V. ;

Lowe, Scott W. .

CELL, 2014, 157 (02) :382-394

[9] RUNX3 Controls a Metastatic Switch in Pancreatic Ductal Adenocarcinoma [J].

Whittle, Martin C. ;

Izeradjene, Kamel ;

Rani, P. Geetha ;

Feng, Libing ;

Carlson, Markus A. ;

DelGiorno, Kathleen E. ;

Wood, Laura D. ;

Goggins, Michael ;

Hruban, Ralph H. ;

Chang, Amy E. ;

Calses, Philamer ;

Thorsen, Shelley M. ;

Hingorani, Sunil R. .

CELL, 2015, 161 (06) :1345-1360

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