Cbfa1 expression is enhanced by the immunosuppressant FK506 in the osteoblastic cell line: UMR106

被引：1

作者：

Iejima, D

Lee, MH

Kojima, H

Yoshikawa, T

Wang, PC

Uemura, T

机构：

[1] Natl Inst Adv Ind Sci & Technol, Age Dimens Res Ctr, Tsukuba, Ibaraki 3058566, Japan

[2] Univ Tsukuba, Inst Appl Biochem, Tsukuba, Ibaraki 3058572, Japan

[3] Kyungpook Natl Univ, Sch Dent, Dept Oral Biochem, Taegu 700422, South Korea

[4] Japan Sci & Technol, Chiyoda Ku, Tokyo 1028666, Japan

[5] Nara Med Univ, Dept Pathol 1, Kashihara, Nara 6348521, Japan

[6] Tokyo Med & Dent Univ, Dept Orthoped Surg, Bunkyo Ku, Tokyo 1138519, Japan

来源：

MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS | 2004年 / 24卷 / 6-8期

关键词：

FK506; Cbta1; osteoblast differentiation; osteopontin; alkaline phosphatase;

D O I：

10.1016/j.msec.2004.08.024

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

An immunosuppressant FK506 has been reported to induce osteoblast differentiation in vivo [J. Bone Miner. Res. 15 (2000) 1147]. To study the role of FK506 in osteoblast differentiation, we examined the mRNA expressions of several marker genes (Cbfa1, osteopontin, and alkaline phosphatase) in an osteoblastic cell line: UMR106-6. Results showed that the Cbfa1 (osteoblast specific transcription factor) expression in UMR cells was enhanced by treatment with FK506, promoting osteoblast differentiation. The effect was marked when simultaneous treatment with FK506 and dexamethasone was given to UMR cells comparing with the effects of treatment with each substance alone or non-treatment. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：845 / 850

页数：6

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