Systems immunology: just getting started

被引：156

作者：

Davis, Mark M. ^{[1
,2
]}

Tato, Cristina M. ^{[2
]}

Furman, David ^{[2
,3
]}

机构：

[1] Stanford Univ, Howard Hughes Med Inst, Sch Med, Stanford, CA 94305 USA

[2] Stanford Univ, Inst Immun Transplantat & Infect, Sch Med, Stanford, CA 94305 USA

[3] Jose de San Martin Clin Hosp, Natl Sci & Tech Res Council, Inst Immunogenet, Buenos Aires, DF, Argentina

来源：

NATURE IMMUNOLOGY | 2017年 / 18卷 / 07期

基金：

美国国家卫生研究院;

关键词：

SEASONAL INFLUENZA; MASS CYTOMETRY; CELL SUBSETS; GENETIC-BASIS; IMMUNE; EXPRESSION; VACCINATION; RESPONSES; SIGNATURES; DECONVOLUTION;

D O I：

10.1038/ni.3768

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Systems-biology approaches in immunology take various forms, but here we review strategies for measuring a broad swath of immunological functions as a means of discovering previously unknown relationships and phenomena and as a powerful way of understanding the immune system as a whole. This approach has rejuvenated the field of vaccine development and has fostered hope that new ways will be found to combat infectious diseases that have proven refractory to classical approaches. Systems immunology also presents an important new strategy for understanding human immunity directly, taking advantage of the many ways the immune system of humans can be manipulated.

引用

页码：725 / 732

页数：8

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