Asprosin, a Fasting-Induced Glucogenic Protein Hormone

被引：433

作者：

Romere, Chase ^{[1
]}

Duerrschmid, Clemens ^{[1
]}

Bournat, Juan ^{[1
]}

Constable, Petra ^{[1
]}

Jain, Mahim ^{[2
]}

Xia, Fan ^{[2
]}

Saha, Pradip K. ^{[1
]}

Del Solar, Maria ^{[6
]}

Zhu, Bokai ^{[1
]}

York, Brian ^{[1
]}

Sarkar, Poonam ^{[3
]}

Rendon, David A. ^{[3
]}

Gaber, M. Waleed ^{[3
]}

LeMaire, Scott A. ^{[4
]}

Coselli, Joseph S. ^{[4
]}

Milewicz, Dianna M. ^{[5
]}

Sutton, V. Reid ^{[2
]}

Butte, Nancy F.

Moore, David D. ^{[1
]}

Chopra, Atul R. ^{[1
,2
]}

机构：

[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

[4] Baylor Coll Med, Michael E DeBakey Dept Surg, Div Cardiothorac Surg, Houston, TX 77030 USA

[5] Univ Texas Med Sch Houston, Dept Internal Med, Houston, TX 77030 USA

[6] Icahn Sch Med Mt Sinai, Dept Pharmacol & Syst Therapeut, New York, NY 10029 USA

来源：

CELL | 2016年 / 165卷 / 03期

关键词：

CONGENITAL LIPODYSTROPHY; MARFAN-SYNDROME; 3' END; MUTATION; FEATURES; MICE; SECRETION;

D O I：

10.1016/j.cell.2016.02.063

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatic glucose release into the circulation is vital for brain function and survival during periods of fasting and is modulated by an array of hormones that precisely regulate plasma glucose levels. We have identified a fasting-induced protein hormone that modulates hepatic glucose release. It is the C-terminal cleavage product of profibrillin, and we name it Asprosin. Asprosin is secreted by white adipose, circulates at nanomolar levels, and is recruited to the liver, where it activates the G protein-cAMP-PKA pathway, resulting in rapid glucose release into the circulation. Humans and mice with insulin resistance show pathologically elevated plasma asprosin, and its loss of function via immunologic or genetic means has a profound glucose- and insulin-lowering effect secondary to reduced hepatic glucose release. Asprosin represents a glucogenic protein hormone, and therapeutically targeting it may be beneficial in type II diabetes and metabolic syndrome.

引用

页码：566 / 579

页数：14

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