A Global Overview of Precision Medicine in Type 2 Diabetes

被引：77

作者：

Fitipaldi, Hugo ^{[1
]}

McCarthy, Mark I. ^{[2
,3
]}

Florez, Jose C. ^{[4
,5
,6
,7
,8
]}

Franks, Paul W. ^{[1
,2
,9
,10
]}

机构：

[1] Lund Univ, Genet & Mol Epidemiol Unit, Dept Clin Sci Malmo, Diabet Ctr,Skane Univ Hosp, Malmo, Sweden

[2] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England

[3] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England

[4] Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA

[5] Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA 02114 USA

[6] Broad Inst, Program Metab, Cambridge, MA USA

[7] Broad Inst, Program Med & Populat Genet, Cambridge, MA USA

[8] Harvard Med Sch, Dept Med, Boston, MA USA

[9] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[10] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

来源：

DIABETES | 2018年 / 67卷 / 10期

基金：

英国惠康基金; 美国国家卫生研究院; 瑞典研究理事会;

关键词：

LIFE-STYLE; PERSONALIZED NUTRITION; TARGET IDENTIFICATION; ENERGY-INTAKE; WEIGHT-LOSS; FOLLOW-UP; ASSOCIATION; PREVENTION; PROGRAM; INSULIN;

D O I：

10.2337/dbi17-0045

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The detailed characterization of human biology and behaviors is now possible at scale owing to innovations in biomarkers, bioimaging, and wearable technologies; "big data" from electronic medical records, health insurance databases, and other platforms becoming increasingly accessible; and rapidly evolving computational power and bioinformatics methods. Collectively, these advances are creating unprecedented opportunities to better understand diabetes and many other complex traits. Identifying hidden structures within these complex data sets and linking these structures to outcome data may yield unique insights into the risk factors and natural history of diabetes, which in turn may help optimize the prevention and management of the disease. This emerging area is broadly termed "precision medicine." In this Perspective, we give an overview of the evidence and barriers to the development and implementation of precision medicine in type 2 diabetes. We also discuss recently presented paradigms through which complex data might enhance our understanding of diabetes and ultimately our ability to tackle the disease more effectively than ever before.

引用

页码：1911 / 1922

页数：12

共 66 条

[1] Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables [J].

Ahlqvist, Emma ;

Storm, Petter ;

Karajamaki, Annemari ;

Martinell, Mats ;

Dorkhan, Mozhgan ;

Carlsson, Annelie ;

Vikman, Petter ;

Prasad, Rashmi B. ;

Aly, Dina Mansour ;

Almgren, Peter ;

Wessman, Ylva ;

Shaat, Nael ;

Spegel, Peter ;

Mulder, Hindrik ;

Lindholm, Eero ;

Melander, Olle ;

Hansson, Ola ;

Malmqvist, Ulf ;

Lernmark, Ake ;

Lahti, Kaj ;

Forsen, Tom ;

Tuomi, Tiinamaija ;

Rosengren, Anders H. ;

Groop, Leif .

LANCET DIABETES & ENDOCRINOLOGY, 2018, 6 (05) :361-369

[2]

[Anonymous], 2014, NAT DIAB STAT REP ES

[3]

[Anonymous], GLOB PREC MED MARK A

[4]

Bergen SE, 2017, AM J MED GENET B, DOI [10. 1002/ajmg. b. 32562, DOI 10.1002/AJMG.B.3256228686353]

[5] 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study [J].

Bray, G. A. ;

Chatellier, A. ;

Duncan, C. ;

Greenway, F. L. ;

Levy, E. ;

Ryan, D. H. ;

Polonsky, K. S. ;

Tobian, J. ;

Ehrmann, D. ;

Matulik, M. J. ;

Clark, B. ;

Czech, K. ;

DeSandre, C. ;

Hilbrich, R. ;

McNabb, W. ;

Semenske, A. R. ;

Goldstein, B. J. ;

Smith, K. A. ;

Wildman, W. ;

Pepe, C. ;

Goldberg, R. B. ;

Calles, J. ;

Ojito, J. ;

Castillo-Florez, S. ;

Florez, H. J. ;

Giannella, A. ;

Lara, O. ;

Veciana, B. ;

Haffner, S. M. ;

Montez, M. G. ;

Lorenzo, C. ;

Martinez, A. ;

Hamman, R. F. ;

Testaverde, L. ;

Bouffard, A. ;

Dabelea, D. ;

Jenkins, T. ;

Lenz, D. ;

Perreault, L. ;

Price, D. W. ;

Steinke, S. C. ;

Horton, E. S. ;

Poirier, C. S. ;

Swift, K. ;

Caballero, E. ;

Jackson, S. D. ;

Lambert, L. ;

Lawton, K. E. ;

Ledbury, S. ;

Kahn, S. E. .

LANCET, 2009, 374 (9702) :1677-1686

[6]

Bu D, 2018, SCIENCE S, pS35

[7] Dietary fat and total energy intake modifies the association of genetic profile risk score on obesity: evidence from 48170 UK Biobank participants [J].

Celis-Morales, C. A. ;

Lyall, D. M. ;

Gray, S. R. ;

Steell, L. ;

Anderson, J. ;

Iliodromiti, S. ;

Welsh, P. ;

Guo, Y. ;

Petermann, F. ;

Mackay, D. F. ;

Bailey, M. E. S. ;

Pell, J. P. ;

Gill, J. M. R. ;

Sattar, N. .

INTERNATIONAL JOURNAL OF OBESITY, 2017, 41 (12) :1761-1768

[8] Effect of personalized nutrition on health-related behaviour change: evidence from the Food4Me European randomized controlled trial [J].

Celis-Morales, Carlos ;

Livingstone, Katherine M. ;

Marsaux, Cyril F. M. ;

Macready, Anna L. ;

Fallaize, Rosalind ;

O'Donovan, Clare B. ;

Woolhead, Clara ;

Forster, Hannah ;

Walsh, Marianne C. ;

Navas-Carretero, Santiago ;

San-Cristobal, Rodrigo ;

Tsirigoti, Lydia ;

Lambrinou, Christina P. ;

Mavrogianni, Christina ;

Moschonis, George ;

Kolossa, Silvia ;

Hallmann, Jacqueline ;

Godlewska, Magdalena ;

Surwillo, Agnieszka ;

Traczyk, Iwona ;

Drevon, Christian A. ;

Bouwman, Jildau ;

van Ommen, Ben ;

Grimaldi, Keith ;

Parnell, Laurence D. ;

Matthews, John N. S. ;

Manios, Yannis ;

Daniel, Hannelore ;

AlfredoMartinez, J. ;

Lovegrove, Julie A. ;

Gibney, Eileen R. ;

Brennan, Lorraine ;

Saris, Wim H. M. ;

Gibney, Mike ;

Mathers, John C. .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2017, 46 (02) :578-588

[9] Design and baseline characteristics of the Food4Me study: a web-based randomised controlled trial of personalised nutrition in seven European countries [J].

Celis-Morales, Carlos ;

Livingstone, Katherine M. ;

Marsaux, Cyril F. M. ;

Forster, Hannah ;

O'Donovan, Clare B. ;

Woolhead, Clara ;

Macready, Anna L. ;

Fallaize, Rosalind ;

Navas-Carretero, Santiago ;

San-Cristobal, Rodrigo ;

Kolossa, Silvia ;

Hartwig, Kai ;

Tsirigoti, Lydia ;

Lambrinou, Christina P. ;

Moschonis, George ;

Godlewska, Magdalena ;

Surwillo, Agnieszka ;

Grimaldi, Keith ;

Bouwman, Jildau ;

Daly, E. J. ;

Akujobi, Victor ;

O'Riordan, Rick ;

Hoonhout, Jettie ;

Claassen, Arjan ;

Hoeller, Ulrich ;

Gundersen, Thomas E. ;

Kaland, Siv E. ;

Matthews, John N. S. ;

Manios, Yannis ;

Traczyk, Iwona ;

Drevon, Christian A. ;

Gibney, Eileen R. ;

Brennan, Lorraine ;

Walsh, Marianne C. ;

Lovegrove, Julie A. ;

Alfredo Martinez, J. ;

Saris, Wim H. M. ;

Daniel, Hannelore ;

Gibney, Mike ;

Mathers, John C. .

GENES AND NUTRITION, 2015, 10 (01)

[10] IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045 [J].

Cho, N. H. ;

Shaw, J. E. ;

Karuranga, S. ;

Huang, Y. ;

Fernandes, J. D. da Rocha ;

Ohlrogge, A. W. ;

Malanda, B. .

DIABETES RESEARCH AND CLINICAL PRACTICE, 2018, 138 :271-281

← 1 2 3 4 5 6 7 →