Synthesis and in vitro antimicrobial evaluation of 5-(1-methyl-5-nitro-2-imidazolyl)-4H-1,2,4-triazoles

被引：36

作者：

Shafiee, A ^{[1
]}

Sayadi, A ^{[1
]}

Roozbahani, MH ^{[1
]}

Foroumadi, A ^{[1
]}

Kamal, F ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Dept Med Chem, Fac Pharm, Tehran 6451, Iran

来源：

ARCHIV DER PHARMAZIE | 2002年 / 335卷 / 10期

关键词：

1,2,4-triazoles; 5-nitroimidazoles; antimicrobial activity;

D O I：

10.1002/ardp.200290004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The increasing clinical importance of drug-resistant pathogens has lent additional urgency to antimicrobial research. Various 5-(l-methyl-5-nitro-2-imidazolyl)-4H-1,2,4-triazoles (4a-6f) were synthesized and tested in vitro for their antibacterial and antifungal activities. Compounds 4a and 4b exhibited significant effects against Bacillus subtilis at MIC ranges of 0.5-1 mug/mL and moderate effects against Staphylococcus aureus.

引用

页码：495 / 499

页数：5

共 19 条

[1]

ASTO G, 1971, Patent No. 3565892

[2]

BOLRON EJ, 1990, BAILY SCETTS DIAGNOS, P173

[3]

BOYLE FT, 1989, Patent No. 122693

[4] NITROIMIDAZOLE DERIVATIVES . RELATIONSHIP BETWEEN STRUCTURE AND ANTITRICHOMONAL ACTIVITY [J].

BUTLER, K ;

HOWES, HL ;

LYNCH, JE ;

PIRIE, DK .

JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (05) :891-&

[5]

CASER C, 1966, ARZNEIMITTEL-FORSCH, V16, P23

[6] SYNTHESIS OF HETEROCYCLES .6. SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME 4-AMINO-5-ARYL-1,2,4-TRIAZOLE-3-THIONES AND THEIR DERIVATIVES [J].

EWEISS, NF ;

BAHAJAJ, AA ;

ELSHERBINI, EA .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1986, 23 (05) :1451-1458

[7] Antituberculosis agents - II. Evaluation of in vitro antituberculosis activity and cytotoxicity of some 2-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazole derivatives [J].

Foroumadi, A ;

Mirzaei, M ;

Shafiee, A .

FARMACO, 2001, 56 (08) :621-623

[8]

FOYE WO, 1989, PRINCIPLES MED CHEM, P734

[9]

HEYES J, Patent No. 2142832

[10]

Jalilian AR, 2000, ARCH PHARM, V333, P347, DOI 10.1002/1521-4184(200010)333:10&lt

← 1 2 →