Thalamic Single-Unit and Local Field Potential Activity in Tourette Syndrome

被引：68
|
作者：
Marceglia, Sara [1 ]
Servello, Domenico [2 ]
Foffani, Guglielmo [3 ,4 ]
Porta, Mauro [2 ]
Sassi, Marco [2 ]
Mrakic-Sposta, Simona [1 ]
Rosa, Manuela [1 ]
Barbieri, Sergio [1 ]
Priori, Alberto [1 ]
机构：
[1] Univ Milan, Fdn IRCCS, Osped Maggiore Policlin, Clin Ctr Neuronanotechnol & Neurostimulat, I-20122 Milan, Italy
[2] Galeazzi Hosp, IRCCS, Funct Neurosurg Tourette Clin, Milan, Italy
[3] Drexel Univ, Sch Biomed Engn Sci & Hlth Syst, Philadelphia, PA 19104 USA
[4] Hosp Nacl Paraplejicos, SESCAM, Toledo, Spain
来源：
MOVEMENT DISORDERS | 2010年 / 25卷 / 03期
关键词：
thalamus; local field potentials; Tourette syndrome; deep brain stimulation; DEEP BRAIN-STIMULATION; SUBTHALAMIC NUCLEUS STIMULATION; PARKINSONS-DISEASE; BASAL GANGLIA; ELECTROPHYSIOLOGICAL LOCALIZATION; OSCILLATORY ACTIVITY; SURGERY; MICRORECORDINGS; MODULATION; RHYTHMS;
D O I：
10.1002/mds.22982
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Deep brain stimulation (DBS) of the ventralis oralis (VO) complex of the thalamus improves tics in patients with Tourette syndrome (TS). To neurophysiologically describe the VO complex we recorded, in seven patients with TS undergoing DBS electrode implantation, single-unit activity during surgery and local field potentials (LFPs) a few days after Surgery. Single unit recordings showed that the VO complex is characterized by a localized pattern of bursting neuronal activity. LFP spectra demonstrated that VO of TS patients has a prominent oscillatory activity at low frequencies (2-7 Hz) and in the a-band (8-13 Hz), and a virtually absent beta activity. In each patient, the main LFP frequency significantly correlated with single-unit interburst frequency. In conclusion, we observed an oscillatory bursting activity in the VO as target region in patients with severe TS Undergoing DBS surgery. (C) 2010 Movement Disorder Society
引用
收藏
页码：300 / 308
页数：9
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