B lymphocytes in inflammatory airway diseases

被引：22

作者：

Drolet, J. -P. ^{[1
]}

Frangie, H. ^{[1
]}

Guay, J. ^{[1
]}

Hajoui, O. ^{[1
]}

Hamid, Q. ^{[1
]}

Mazer, B. D. ^{[1
]}

机构：

[1] McGill Univ, Ctr Hlth, Res Inst, Meakins Christie Labs, Montreal, PQ H2X 2P2, Canada

来源：

CLINICAL AND EXPERIMENTAL ALLERGY | 2010年 / 40卷 / 06期

关键词：

LYMPHOID-TISSUE BALT; NASAL-MUCOSA; PLASMA-CELLS; GERMINAL CENTER; LOCAL PRODUCTION; IGE PRODUCTION; LUNG; HYPERRESPONSIVENESS; EXPRESSION; RHINITIS;

D O I：

10.1111/j.1365-2222.2010.03512.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

B lymphocytes are key players in all facets of adaptive immune responses and are responsible for the production of IgE antibodies, initiators of allergic hypersensitivity reactions. Recent evidence indicates that B cells may be a crucial player in allergic and inflammatory airway pathology, directly populating upper and lower airway tissues. This review examines human and animal studies that directly demonstrated the presence of B lymphocytes in airway tissues and elaborates on their function as antibody-secreting cells, antigen-presenting cells and producers of inflammatory and regulatory cytokines. B lymphocytes appear to contribute to multiple facets of immune homeostasis in inflammatory diseases of the upper and lower airways.

引用

页码：841 / 849

页数：9

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