Transethnic Transferability of a Genome-Wide Polygenic Score for Coronary Artery Disease

被引：27

作者：

Fahed, Akl C. ^{[1
,2
,3
,4
,5
]}

Aragam, Krishna G. ^{[2
,3
,4
,5
]}

Hindy, George ^{[6
]}

Chen, Yii-Der Ida ^{[7
]}

Chaudhary, Kumardeep ^{[8
]}

Dobbyn, Amanda ^{[8
]}

Krumholz, Harlan M. ^{[9
,10
]}

Sheu, Wayne H. H. ^{[11
]}

Rich, Stephen S. ^{[12
]}

Rotter, Jerome I. ^{[7
]}

Chowdhury, Rajiv ^{[13
]}

Cho, Judy ^{[8
]}

Do, Ron ^{[8
]}

Ellinor, Patrick T. ^{[2
,3
,4
,5
]}

Kathiresan, Sekar ^{[2
,3
,5
,14
]}

Khera, Amit V. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Genom Med, Dept Med, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA 02114 USA

[3] Harvard Med Sch, Dept Med, Boston, MA 02115 USA

[4] Broad Inst MIT & Harvard, Cardiovasc Dis Initiat, Cambridge, MA 02142 USA

[5] Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA

[6] Qatar Univ, Dept Populat Med, Coll Med, QU Hlth, Doha, Qatar

[7] Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat, Torrance, CA 90509 USA

[8] Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, Dept Genet & Genom Sci, New York, NY 10029 USA

[9] Yale Univ, Sch Med, Dept Med, Sect Cardiovasc Med, New Haven, CT 06510 USA

[10] Yale Univ, Sch Med, Dept Med, Robert Wood Johnson Clin Scholars Program, New Haven, CT 06510 USA

[11] Natl Yang Ming Univ, Sch Med, Taichung Vet Gen Hosp, Dept Med, Taipei, Taiwan

[12] Univ Virginia, Sch Med, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA

[13] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England

[14] Verve Therapeut, Cambridge, MA USA

来源：

CIRCULATION-GENOMIC AND PRECISION MEDICINE | 2021年 / 14卷 / 01期

关键词：

coronary artery disease; genetics; humans; meta-analysis; race; RISK;

D O I：

10.1161/CIRCGEN.120.003092

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页数：4

共 5 条

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[4] Whole-Genome Sequencing to Characterize Monogenic and Polygenic Contributions in Patients Hospitalized With Early-Onset Myocardial Infarction
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[5] Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations
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