Diagnostic criteria for apathy in neurocognitive disorders

被引：101

作者：

Miller, David S. ^{[1
]}

Robert, Philippe ^{[2
,3
,4
]}

Ereshefsky, Larry ^{[5
]}

Adler, Lawrence ^{[6
]}

Bateman, Daniel ^{[7
]}

Cummings, Jeff ^{[8
,9
]}

DeKosky, Steven T. ^{[10
]}

Fischer, Corinne E. ^{[11
,12
]}

Husain, Masud ^{[13
,14
,15
]}

Ismail, Zahinoor ^{[16
]}

Jaeger, Judith ^{[17
]}

Lerner, Alan J. ^{[18
]}

Li, Abby ^{[19
]}

Lyketsos, Constantine G. ^{[20
]}

Manera, Valeria ^{[2
,3
]}

Mintzer, Jacobo ^{[21
,22
]}

Moebius, Hans J. ^{[23
]}

Mortby, Moyra ^{[24
]}

Meulien, Didier ^{[25
]}

Pollentier, Stephane ^{[26
]}

Porsteinsson, Anton ^{[27
]}

Rasmussen, Jill ^{[28
]}

Rosenberg, Paul B. ^{[20
]}

Ruthirakuhan, Myuri T. ^{[19
]}

Sano, Mary ^{[29
]}

Sarracini, Carla Zucchero ^{[19
]}

Lanctot, Krista L. ^{[19
,30
,31
]}

机构：

[1] Signant Health, Blue Bell, PA USA

[2] Univ Cote dAzur, Cognit Behav Technol Lab, Nice, France

[3] Assoc Innovat Alzheimer, Nice, France

[4] Univ Nice, Ctr Memoire, Ctr Hosp, Nice, France

[5] Follow Mol, Marina Del Rey, CA USA

[6] Univ Maryland, Sch Med, Dept Psychiat, Baltimore, MD 21201 USA

[7] Indiana Univ Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA

[8] Univ Nevada, Sch Integrated Hlth Sci, Dept Brain Hlth, Las Vegas, NV USA

[9] Cleveland Clin, Lou Ruvo Ctr Brain Hlth, Las Vegas, NV USA

[10] Univ Florida, Dept Neurol, McKnight Brain Inst, Gainesville, FL USA

[11] Univ Toronto, Inst Med Sci, Toronto, ON, Canada

[12] St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr Biomed Res, Toronto, ON, Canada

[13] Univ Oxford, Dept Expt Psychol, Oxford, England

[14] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, England

[15] Oxford NIHR Biomed Res Ctr, Oxford, England

[16] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB, Canada

[17] CognitionMetrics, Wilmington, DE USA

[18] Case Western Reserve Univ, Univ Hosp, Cleveland, OH USA

[19] Sunnybrook Res Inst, Toronto, ON, Canada

[20] Johns Hopkins Univ, Baltimore, MD USA

[21] Med Univ South Carolina, Charleston, SC 29425 USA

[22] Ralph H Johnson Vet Adm Med Ctr, Charleston, SC USA

[23] Moebius Consult, Baar, Switzerland

[24] Univ New South Wales, UNSW Ageing Futures Inst, Sydney, NSW, Australia

[25] H Lundbeck & Co AS, Clin Res & Dev, Valby, Denmark

[26] Boehringer Ingelheim Pharma GmbH & Co KG, CNS Dis Res, Biberach, Germany

[27] Univ Rochester, Rochester, NY USA

[28] Psi Napse, Dorking, Surrey, England

[29] Icahn Sch Med Mt Sinai, Dept Psychiat, Alzheimer Dis Res Ctr, New York, NY USA

[30] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[31] Univ Toronto, Dept Pharmacol Toxicol, Toronto, ON, Canada

来源：

ALZHEIMERS & DEMENTIA | 2021年 / 17卷 / 12期

关键词：

apathy; behavior; cognition; diagnostic criteria; emotion; motivation; neurocognitive disorder (NCD); neuropsychiatric symptoms (NPS); MILD COGNITIVE IMPAIRMENT; NURSING-HOME RESIDENTS; DISEASE RATING-SCALE; ALZHEIMERS-DISEASE; NEUROPSYCHIATRIC SYMPTOMS; PARKINSONS-DISEASE; FRONTOTEMPORAL DEMENTIA; NONPHARMACOLOGICAL TREATMENT; PSYCHOMETRIC PROPERTIES; AMYLOID BURDEN;

D O I：

10.1002/alz.12358

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction Apathy is common in neurocognitive disorders (NCD) but NCD-specific diagnostic criteria are needed. Methods The International Society for CNS Clinical Trials Methodology Apathy Work Group convened an expert group and sought input from academia, health-care, industry, and regulatory bodies. A modified Delphi methodology was followed, and included an extensive literature review, two surveys, and two meetings at international conferences, culminating in a consensus meeting in 2019. Results The final criteria reached consensus with more than 80% agreement on all parts and included: limited to people with NCD; symptoms persistent or frequently recurrent over at least 4 weeks, a change from the patient's usual behavior, and including one of the following: diminished initiative, diminished interest, or diminished emotional expression/responsiveness; causing significant functional impairment and not exclusively explained by other etiologies. Discussion These criteria provide a framework for defining apathy as a unique clinical construct in NCD for diagnosis and further research.

引用

页码：1892 / 1904

页数：13

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