The role of antihistaminic effects in the misuse of quetiapine: A case report and review of the literature

被引：27

作者：

Fischer, Bernard A. ^{[1
,2
]}

Boggs, Douglas L. ^{[1
]}

机构：

[1] Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Catonsville, MD 21228 USA

[2] MIRECC, Vet Affairs Capital Network VISN 5, Baltimore, MD USA

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2010年 / 34卷 / 04期

关键词：

Quetiapine; Antipsychotic; Substance misuse; Substance abuse; Antihistamine; D-2; RECEPTORS; ABUSE; DRUG; DOPAMINE; DIPHENHYDRAMINE;

D O I：

10.1016/j.neubiorev.2009.11.003

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Recent case reports and case series suggest that the atypical antipsychotic quetiapine has the potential for misuse. This includes drug-seeking behaviors motivated by quetiapine as well as inappropriate (intranasal or intravenous) administration. We present an additional case of quetiapine misuse and review other published cases. In general, quetiapine misuse is associated with prior CNS depressant use and is more common in forensic settings. The mechanism of reinforcement for this misuse is unknown, but we hypothesize that it is related to quetiapine's pharmacological profile as an antihistamine with a relative low affinity for dopamine receptors. The risks to individuals and society of exaggerating/simulating symptoms to obtain high-dose quetiapine in the absence of a clinical indication are discussed. This includes the unwelcome possibility of restricting access to this effective medication. Published by Elsevier Ltd.

引用

页码：555 / 558

页数：4

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